Clinical Study On The Treatment Of Branch Retinal Vein Occlusion Of Qi Deficiency And Blood Stasis Type With The Method Of Replenishing Qi And Activating Blood Circulatio

Objective: To observe the clinical effect of replenishing Qi and activating blood therapy in the treatment of branch retinal vein occlusion of Qi deficiency with blood stasis.Methods:1.Select 40 patients with macular edema due to branch retinal vein occlusion of Qi deficiency with blood stasis in ophthalmology department of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,and randomly divid them into therapy group and control group(20 cases in each)according to the order of medical treatment.2.Control group: Intravitreal injection of anti-VEGF drug(Conbercept injection),1 injection first,then on-demand injection within 2mo(OCT showed that the central retinal thickness was >250um and macular edema,the principle of 1+PRN treatment was adopted,Re-injection can be done 1 month after the last injection).Therapy group: On the basis of the control group,combined with Chinese medicine dialectical application of Qidan Mingmu Decoction,one dose a day,blistered,divided into two warm doses,and taken for 2mo.The patients in the two groups received the clinical trial plan and received continuous treatment,and were observed for 2mo;3.The TCM syndrome score,best corrected visual acuity(BCVA),central retinal thickness(CRT)and fundus hemorrhage area of Qi deficiency with blood stasis syndrome in the therapy group and the control group were observed at 1mo before treatment and 1mo and 2mo after treatment,respectively,and the observation indexes and total efficacy were analyzed.Results: At the end of the study,3 patients were detached,including 2 in the therapy group and1 in the control group1.There was no significant difference in TCM syndrome score,BCVA,CRT and fundus hemorrhage area between the two groups before treatment(P>0.05);2.BCVA: After treatment,the therapy group increased to 0.49±0.22,and the control group increased to 0.35±0.26,with statistical difference between the two groups(P<0.05);3.CRT: After treatment,the decrease in the therapy group was 225.56±32.51,and the decrease in the control group was 351.00±173.57,with statistical difference between the two groups(P<0.05);4.Fundus hemorrhage area: after treatment,the therapy group decreased to 5.83±2.23,and the control group decreased to 8.26±3.53,with statistical difference between the two groups(P<0.05);5.Efficacy evaluation: Traditional Chinese medicine syndrome efficacy: the effective rate of the control group was 36.8%,the effective rate of the treatment group was 72.2%,and there was a statistical difference between the two groups(P<0.05);BCVA efficacy: the effective rate of the control group was 57.9%,and the effective rate of the treatment group was 88.9 %,there was a statistical difference between the two groups(P<0.05);6.After treatment,the two groups had advantages in TCM syndrome efficacy,BCVA efficacy,Best corrected visual acuity(BCVA),CRT,and Fundus hemorrhage area compared with those before treatment,with statistical differences(P<0.05).Conclusion:1.Intravitreal injection of anti-VEGF drugs can effectively reduce macular edema due to BRVO, improve patients’ visual acuity,reduce the area of fundus hemorrhage,and improve TCM syndrome scores.2.The treatment of replenishing Qi and activating blood therapy circulation combined with intravitreal injection of anti-VEGF drug for the treatment of macular edema due to branch retinal vein occlusion of Qi deficiency with blood stasis is superior to anti-VEGF drug treatment alone in improving BCVA,reducing TCM syndrome score,Central retinal thickness and Fundus hemorrhage area.