Research On The Application Of Metal Organic Framework (MOF) And Platelet Composite Fibers In Burns And Scald

After skin wounds occur,wound healing is achieved through rapid coagulation and hemostasis,prophase and mid-stage inflammatory responses,fibroblast proliferation and tissue remodeling.Usually,burns wounds take too long to recover and are prone to bacterial infection and microbial invasion,which can prevent the speed of wound healing.At this stage,hospitals generally use gauze and ointment to treat burns.Due to the high porosity of the gauze and the poor adhesion to the skin,it is not conducive to preventing the invasion of external bacteria.As an exogenous drug,ointment has a relatively single component and needs to be used in combination,and the drug is too viscous,and the exudate from the wound cannot be fully and effectively drained after smearing,which is easy to aggravate the inflammatory reaction or even infection of the wound.different.Therefore,it is of great significance to develop synergistic treatment of two or more materials.In the third chapter of this paper,we combined electrospinning technology and zeolite imidazole framework material(ZIF-8)material for drug loading,and proposed a seedless method to prepare composite nanofiber membranes with high antibacterial effect.The fibers prepared by the method do not appear that ZIF-8 crystals are encapsulated in the fibers,or ZIF-8 crystals overfill the fibers.At the same time,the fibrous membrane exhibits a larger specific surface area,which is beneficial to increase the drug loading capacity of the drug.The test results found that the drug loading capacity increased from the previous15% to 25%.Antibacterial tests showed that ZIF-8 and polylysine(εPL)exhibited dual antibacterial properties,and εPL was loaded onto ZIF-8 as a polypeptide to further kill residual bacteria.The PCL@ZIF-8/εPL fibrous membrane can prevent the infection of the wound by external bacteria,and its efficient bactericidal properties make it used as a burn dressing to promote the healing of burn wounds,shortening from 22 days to 17 days.Chapter 4 of this paper presents an in-situ handheld electrospinning device that can be used outdoors to fabricate composite nanofiber membranes with coaxial structures.This method encapsulates PRP into nanofibers with antibacterial properties,which not only protects the activity of growth factors,but also achieves the effect of sustained release and maintains the concentration required for wound healing.The fibers deposited in situ have better adhesion to the skin,which can avoid the contact of external bacteria in wound healing and protect the wound.The fibers exhibited excellent antibacterial properties and tissue regeneration-promoting properties,and a composite nanofiber with antibacterial,anti-inflammatory and growth-promoting properties was constructed for burn wound repair.