Analysis Of TCM Syndrome Types And Related Factors Of Pancreatic Cancer Combined With Type 2 Diabete

Purpose:To analyze and investigate the Chinese medical evidence and related factors in patients with pancreatic cancer combined with type 2 diabetes mellitus.Material and method:This study retrospectively analyzed the data of pancreatic cancer patients admitted to the Department of Oncology of the Affiliated Hospital of Liaoning University of Chinese Medicine from September 2017 to September 2021.Microsoft Excel software was used to analyze the age,gender,history of hypertension,tumor location,distant metastasis,first symptoms,whether surgery was performed,whether history of radiotherapy was given and tumor markers: carcinoembryonic antigen(CEA),glycoantigen 199(CA19-9),glycoantigen 125(CA12-5),duration of diabetes,mode of glucose lowering,and the four diagnostic data of Chinese medicine(symptoms,tongue and pulse)of patients with combined diabetes and by using SPSS26.0 software to perform chi-square test or Fisher test and K-means cluster analysis.Results:1.A total of 112 patients with pancreatic cancer were included in the criteria according to the inclusion and exclusion criteria,including 31 patients with combined type 2 diabetes mellitus and 81 patients without combined type 2 diabetes mellitus.2.Using K-means clustering analysis,the distribution of the TCM evidence types in patients with pancreatic cancer combined with type 2 diabetes was as follows: Spleen deficiency and damp-heat evidence > stagnant qi stagnation evidence > damp-heat and toxic evil evidence >positive deficiency and toxic evil evidence;the distribution of the TCM evidence types in patients without type 2 diabetes was as follows: stagnant qi stagnation evidence > spleen deficiency and damp-heat evidence > positive deficiency and toxic evil evidence > damp-heat and toxic evil evidence.3.The occurrence of pancreatic cancer combined with type 2 diabetes mellitus in 112 cases was not statistically significant(P>0.05)in relation to gender,age,history of hypertension,history of smoking and drinking,tumor location,history of surgery,history of radiotherapy,distant metastasis and CA19-9,suggesting no correlation.There was a statistically significant correlation(P<0.05)with first symptoms,CEA,CA12-5,syndrome of TCM,mode of glucose lowering and duration of diabetes mellitus,suggesting a correlation.Conclusion:1.The TCM evidence types of pancreatic cancer patients include stasis and qi stagnation evidence,damp-heat and toxic evil evidence,spleen deficiency and damp-heat evidence,and positive deficiency and evil evidence.2.Patients with pancreatic cancer combined with type 2 diabetes mellitus were mostly suffering from spleen deficiency and damp-heat,tend to have mixed evidence of deficiency and actuality;patients without type 2 diabetes mellitus were mostly suffering from stasis and qi stagnation,tend to have evidence of standard actuality.3.The patients with pancreatic cancer with short duration of diabetes are mainly empirical;while the patients with pancreatic cancer with long duration of diabetes are mainly mixed with virtual and real.The more types and quantities of hypoglycemic drugs used,the greater the toxicity,so the syndrome type is mostly damp-heat toxins.4.Type 2 diabetes was combined in 27.68%(31/112)of cases of pancreatic cancer patients,which is higher than the overall prevalence of diabetes in the same age group,suggesting a correlation between the two.Patients with combined type 2 diabetes are more likely to have no first symptoms and are more likely to have elevated CEA and CA12-5 than those without combined diabetes.Patients with type 2 diabetes should be screened early to be alert for pancreatic cancer.