Study On Risk Factors And TCM Syndrome Types Of Type 2 Diabetes Combined With Lacunar Cerebral Infarctio

Purpose:The aim of this study was to retrospectively analyze the medical records of patients with type 2 diabetes mellitus combined with lacunar cerebral infarction in terms of their general condition,relevant physical and chemical indices and TCM evidence patterns,in order to comprehensively explore the factors associated with the disease,the distribution of TCM evidence patterns and their relationship with each factor.Material and method:The medical records of patients with type 2 diabetes mellitus hospitalized in the Department of Endocrinology of the Rehabilitation Centre of Liaoning University of Chinese Medicine and the Department of Endocrinology of the Affiliated Hospital of Liaoning University of Chinese Medicine between October 2020 and October2021 were collected and collated.The patients were divided into two groups,type 2 diabetes group(group A)and type 2 diabetes combined with lacunar cerebral infarction group(group B),based on whether they had lacunar cerebral infarction or not.Subsequently,gender,age,duration of diabetes,history of coronary heart disease,history of hypertension,history of smoking,history of alcohol consumption,body mass index(BMI),glycated haemoglobin(Hb A1c),triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(Apo A1) Apolipoprotein B(Apo B),lysophosphatidic acid(LPa),uric acid(UA),C-reactive protein(CRP),urea(UREA),creatinine(CREA),fibrinogen(FIB),activated partial thromboplastin time(APTT),platelet count(PLT),α1-microglobulin(α1-MG),estimated glomerular filtration rate(e GFR),serum Cystatin C(Cys-C)and other relevant indicators,comorbidities,TCM evidence status and other information were recorded and statistically analysed.SPSS26.0 was applied to complete the statistical processing of the relevant data to analyze the factors associated with type 2 diabetes mellitus combined with lacunar cerebral infarction,and to observe the distribution of Chinese medical evidence in patients with type 2 diabetes mellitus combined with lacunar cerebral infarction and its relationship with each factor.Results:1.Comparing the data between group A and group B,the duration of diabetes,history of hypertension,history of coronary heart disease and serum cystatin C(Cys-C),were statistically different between the two groups(P < 0.05).2.Logistic regression analysis showed that history of coronary heart disease was a risk factor associated with type 2 diabetes mellitus combined with lacunar cerebral infarction(P < 0.05).3.The frequency of complications or comorbidities in the 60 patients with type 2 diabetes mellitus combined with lacunar cerebral infarction was,in descending order,lower limb arteriosclerosis(55 cases)> peripheral neuropathy(52 cases)> carotid arteriosclerosis(44 cases)> diabetic nephropathy(22 cases).4.60 patients with type 2 diabetes mellitus combined with lacunar cerebral infarction had the following TCM evidence types in order of prevalence: Qi-Yin deficiency with blood stasis(28 cases)> Qi-Yin deficiency(16 cases)> Phlegm-Dampness blockage of ligaments(11 cases)> Liver-Kidney Yin deficiency(5 cases).5.60 patients with type 2 diabetes mellitus combined with lacunar cerebral infarction had statistical differences in age,duration of diabetes mellitus,urea(UREA),serum cystatin C(Cys-C)and α1-microglobulin(α1-MG)between the four groups(P < 0.05).The age and duration of diabetes were higher in patients with liver and kidney yin deficiency than in patients with other types of evidence(P < 0.05).Conclusion:1.The occurrence of type 2 diabetes mellitus combined with lacunar cerebral infarction was associated with the duration of diabetes mellitus,history of hypertension,history of coronary artery disease,and serum cystatin C(Cys-C),and the history of coronary artery disease was a risk factor associated with the development of type 2 diabetes mellitus combined with lacunar cerebral infarction.2.Patients with type 2 diabetes mellitus combined with lacunar cerebral infarction are most likely to have combined or concurrent lower limb atherosclerosis.3.The distribution of TCM evidence of type 2 diabetes mellitus combined with lacunar cerebral infarction: Qi-Yin deficiency with blood stasis > Qi-Yin deficiency >Phlegm-Dampness obstruction > Liver-Kidney Yin deficiency.4.Type 2 diabetes combined with lacunar cerebral infarction was associated with age,duration of diabetes,urea(UREA),serum cystatin C(Cys-C)and α1-microglobulin(α1-MG).Patients with liver and kidney yin deficiency were older and had a longer duration of diabetes than those with the other types.