| Purpose:To analyze the factors affecting type 2 diabetes mellitus(T2DM)and lower extremity arteriosclerotic diseases(LEAD),the distribution of TCM constitution in patients with T2 DM and LEAD,and the correlation between different constitutions and clinical indices,in order to provide a basis for combining Chinese and Western medicine in the treatment of T2 DM and LEAD.This study will provide a basis for combining Chinese and Western medicine in the treatment of T2 DM and LEAD.Material and method:A total of 306 patients with type 2 diabetes mellitus and LEAD who fulfilled the criteria and were hospitalized at the Department of Endocrinology of the Affiliated Hospital of Liaoning University of Chinese Medicine from October 2020 to November 2021 were studied.To collect patients’ status in terms of gender,age,disease duration,blood pressure,waist circumference(WC),body mass index(BMI)and visceral fat area(VFA)were collected;Drawing of venous blood in the immediate morning on an unoccupied diet,and fasting blood glucose(FPG),fasting C-peptide(FCP),glycated haemoglobin(Hb A1c),triglycerides(TG),total cholesterol(TC),low-density lipoprotein(LDL-C),High Density Lipoprotein(HDL-C),Glutathione Transaminase(ALT),Glutathione Aminotransferase(AST),Blood Uric Acid(SUA)and other physicochemical indicators.Patients completed the TCM Body Composition Questionnaire quantitative form according to their own condition in the past 6 months,and the researchers calculated the corresponding scores according to the patients’ completion.The data collected from the TCM Body Composition Questionnaire with general conditions and physical and chemical indicators were entered into an Excel sheet and statistically analysed using SPSS 24.0 statistical software;normally distributed data were expressed as mean ± standard deviation(X ± S),non-normally distributed measures were expressed as median(four scores)[M(P25,P75)] and count data were expressed using chi-square test,expressed with composition ratios and percentages(n,%);measures that met the chi-square of normal distribution were tested using t-tests for independent samples and one-way ANOVA.If normality and chi-squaredness were not satisfied,non-parametric tests were used.Correlations between TCM body mass and study indicators were analysed using multicategorical logistic regression analysis P<0.05 suggesting statistical differences.Results:1.General information of patients with type 2 diabetes mellitus and LEADA total of 306 patients with type 2 diabetes mellitus and LEAD were included in this study,of whom 172(56.21%)were male and 134(43.79%)were female,with a male to female sex ratio of 1.28:1.The mean duration of illness was 9.48 ± 7.74 years and the mean age of the patients was 59.10 ± 10.51 years,with an overall predominance of elderly patients.2.Distribution of TCM constitution in patients with type 2 diabetes mellitus and LEADThe distribution of the nine body types in 306 patients with type 2 diabetes mellitus and LEAD,in descending order,was as follows: Yin deficiency in 69 cases(22.5%),Phlegm-damp in 68 cases(22.0%),Blood stasis in 40 cases(13.1%),Qi deficiency in 33 cases(10.8%),Damp-heat in 31 cases(10.1%),Yang deficiency in 24 cases(7.8%),Pinghe in 18cases(5.9%),Qi-yu in 17 cases(5.6%),and Qi-yu in 17 cases(5.6%).17 cases(5.6%),and 6cases(2%)of endowment.3.Analysis of TCM constitution and physical and chemical indicators in patients with type 2diabetes mellitus and LEADThe mean BMI of the patients in this study was 25.26±3.46kg/m2,with phlegm-damp and damp-heat patients having the highest BMI,with statistically significant differences compared to the rest of the body types(P<0.05)The highest TG levels were found in Damp-Heat patients,and the highest TC,HDL-C and LDL-C levels were found in Yin-Deficiency patients,with statistically significant differences when compared with the rest of the body types(P<0.05).Damp-Heat patients had higher SUA levels,with statistically significant differences compared to the rest of the body types(P<0.05).Damp-Heat and Phlegm-Damp patients had higher visceral fat thickness,and the difference was statistically significant(P<0.05)when compared to the rest of the body types.4.Correlation between TCM constitution and study indicatorsLDL-C is positively associated with Yin deficiency,VFA is positively associated with phlegm-dampness and SUA is positively associated with damp-heat.Conclusion:1.Yin deficiency,phlegm-dampness,blood stasis and qi deficiency are the main TCM constitutions in type 2 diabetes mellitus with LEAD.Clinical practice should focus on the use of treatments such as benefiting qi and nourishing yin,resolving phlegm and dispelling dampness,and activating blood circulation.2.BMI,VFA,TG,TC,HDL-C,LDL-C and SUA are the factors affecting the TCM constitution of type 2 diabetes mellitus with lower limb atherosclerosis.3.LDL-C is positively associated with Yin deficiency,VFA is positively associated with phlegm-dampness and SUA is positively associated with damp-heat. |
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