Data Mining-based Collation Of Qing Dynasty Medical Literature And Clinical Experience In Treating Tachyarrhythmia

Tachyarrhythmia is a common arrhythmia in clinical practice,including sinus tachycardia,atrial premature contraction,atrial fibrillation,etc.With the change of modern lifestyle,the incidence population tends to be younger.If not timely prevention and treatment,the disease may be progressive aggravation,leading to the occurrence of cardiovascular risk events.It is classified into the category of "palpitation" in traditional Chinese medicine,which has advantages in the treatment and improvement of the symptoms and prognosis of tachyarrhythmia.The royal court medicine belongs to the medicine of the motherland.Because the development of medicine in each dynasty was close to the ruling class,the royal court medicine played an important role in the development of medicine.The Qing Dynasty was the last feudal dynasty in China,and it was also a great achievement in collecting the achievements of imperial medicine.The imperial doctor Wu Qian compiled the "Yuzuan Yizong Jinjian" and the team of traditional Chinese medicine master Chen Keji organized the original medical archives of the Qing Palace and compiled the "Qing Palace Medical Records Compilation"which can reveal the characteristics of the palace diagnosis and treatment of diseases.My Professor Zhang Jingchun,inherited Chinese royal court medicine with Mr.Chen,dug deeply into the literature related to the palpitations of the imperial medical cases of the Qing Dynasty,explored the treatment methods and prescription concepts,and absorbed the essence,so as to benefit the modern clinical treatment of tachyarrhythmia.Study 1:Based on data mining,explore the prescription and medication rules of imperial medicine for palpitations in the Qing DynastyObjective:To excavate the prescriptions for the treatment of palpitations in the imperial medical literature of the Qing Dynasty,and to explore and analyze the rules of prescription and medication for palpitations in the imperial treatment of the Qing Dynasty.Methods:Prescriptions for palpitation in the Imperial Compilation of Medical Records"Yuzuan Yizong Jinjian"and the"Qing Palace Medical Records Compilation"edited by academician Chen Keji were selected to establish a database.The traditional Chinese medicine inheritance auxiliary platform was used for data mining,and the drugs and prescription rules were revealed by analyzing the frequency and meridian attribution of drugs,association rules and complex entropy clustering algorithms.Results:1.208 prescriptions for treating palpitations in the imperial medical literature of the Qing Dynasty were sorted out,and 237 Chinese herbs were obtained.2.The top ten TCM prescriptions were Poria cocos,Radix paeoniae alba,raw Rehmannia,Fu Shen,licorice,Tangerine peel,Ophiopogonis ophiopogonis,Angelica sinensis,mulberry leaf and chrysanthemum.The four qi of traditional Chinese medicine are mostly cold,warm and flat,and the five tastes are bitter,spicy and sweet.The frequency of returning meridians of traditional Chinese medicine was spleen meridian,lung meridian,liver meridian,stomach meridian,heart meridian,kidney meridian,etc.3.Based on the association rule apriori algorithm,the high-frequency drug combinations were obtained as "raw dihuang,Baishao","Baishao,Fu Shen","mulberry leaves,chrysanthemum","Baishao,Poria","raw Dihuang,Fu Shen",etc.and 15 new prescriptions were obtained by complex entropy clustering algorithm.Conclusion:① The royal court medicine of the Qing Dynasty understood that the etiology and pathogenesis of palpitations were similar to those of modern traditional Chinese medicine,always with deficiency of the essence and excess of the standard,and the pathogenesis was mostly qi and blood weakness and malnutrition of the heart vessel.In the treatment,sweet and mild herbs were used to supplement qi and blood,such as "licorice,Poria","Tangerine,licorice",etc.②Attention should be paid to the regulation of the liver.In the prescriptions,drugs for regulating the liver meridian are often used to soothe the liver and regulate qi,regulate the qi apparatus,and make the blood vessels unblocked,such as Xiangfu,woody incense,bitter bitter fruit,etc.③In treatment,tonifying deficiency without forgetting to reduce excess,nourishing the mind and relieving heat at the same time,commonly used drugs include mulberry leaves,chrysanthemum,paeony,etc.Study 2:The clinical experience of Professor Zhang Jingchun in the treatment of tachyarrhythmia was studied based on data mining.Objective:To investigate the clinical data of Professor Zhang Jingchun in the treatment of tachyarrhythmia,explore the rules of prescription and medication,and summarize the thoughts and experience of diagnosis and treatment of tachyarrhythmia.Methods:The data of patients with tachyarrhythmia treated in Professor Zhang’s outpatient clinic from October 1,2020 to October 1,2022 were collected,and a database was established.Data mining was conducted on the traditional Chinese Medicine inheritance assistance platform.Results:(1)205 valid clinical data of Professor Zhang’s outpatient treatment of tachyarrhythmia were collected.The number of female patients was higher than that of male patients.The age of the patients ranged from 19 to 87 years old,and the young and middle-aged people accounted for about 42.4%,and the elderly people accounted for 57.6%.Type 2 diabetes mellitus,cardiac radiofrequency ablation and coronary heart disease were the most common complications of tachyarrhythmia.2.Professor Zhang’s outpatient treatment of tachyarrhythmia,the top ten commonly used drugs in turn are Gansong,jujube seed,white paeony,Rhizoma corynetii,fried licorice,ophiorrhiza,calcured oysters,Codonopsis ginseng,Xianhecao,and cinnamomum twig.The use of traditional Chinese medicine is mostly warm,cold,and smooth,and the taste is sweet,bitter,and spicy.The types of drugs are mainly used for invigorating qi,soothing liver and relieving wind,invigorating blood,regulating qi,etc.3.Based on the association rule Apriori algorithm,the most frequently used drug combinations were "Ganshu pine,jujube kernel" "Baishao,ganshu pine" "Baishao,jujube kernel" "fried licorice root,Ganshu pine" "Corydalis yanhu,Ganshu pine" and so on.Based on the complex entropy clustering algorithm,12 new prescriptions were obtained.Conclusions:The incidence of tachyarrhythmia tends to be younger,and the majority of patients are elderly,and tachyarrhythmia is often complicated with a variety of heart diseases such as hypertension,coronary heart disease and type 2 diabetes mellitus.In the treatment of tachyarrhythmia,Professor Zhang would draw on the court medicine of the Qing Dynasty,pay attention to the deficiency of the original and the excess of the criteria,treat from the liver,spleen and heart,use the products for soothing the liver and relieving depression,give consideration to supplementing qi and blood,nourishment of the mind,strengthening the body and eliminating pathogenic factors,use the multi-flavor of medicinal herbs to strengthen and reduce the disease,pay attention to the differences in the patients’ constitution,the clinical emphasis is different,pay attention to health education,the combination of medicine and nourishment,and follow the four seasons.The treatment of cardiovascular diseases from the liver is the characteristic of its treatment.In clinical practice,it is good at treating tachyarrhythmia with hypertension,bad mood and insomnia in different ages.