Exploring The Medication Rules For Stroke Based On Ancient Medical Records And Chinese Patent Medicine

Objective:To analyze the compatibility and medication law of ancient medical records and Chinese patent medicines for stroke included in 2020 Chinese Pharmacopoeia(Part I);To provide ideas and references for clinical medication.Methods:1.Collect medical records for treating stroke from the "Chinese Medical Dictionary"(5th edition),"Chinese Medical Dictionary",and related medical record books.Use the data mining module of the ancient and modern medical record cloud platform(V2.3.5)system to conduct frequency statistics,association rule analysis,and cluster analysis on the internal medication for treating stroke in ancient medical records.2.The Chinese patent medicines for stroke in the Pharmacopoeia were screened and collated,and frequency of medicine,properties and flavors,association rules,and clustering were under analysis by the Ancient and Modern Medical Record Cloud Platform(V2.3.5).Results:1.254 medical records for treating stroke in ancient books were included in this study,and 254 traditional Chinese medicine formulas were used for frequency statistics,involving a total of 306 drugs,with a total frequency of 2765 times.16 high-frequency drugs with a frequency of ≥ 11 were used.According to the frequency statistics of traditional Chinese medicine,the most frequent drug was Pinellia ternata,with a frequency of 95 and 34.67%.Secondly,licorice,Poria cocos,white peony,ginseng,Angelica sinensis,Ophiopogon japonicus,tangerine peel,Atractylodes macrocephala,bamboo juice,Gastrodia elata,Acorus calamus,raw earth,Aconite,Achyranthes bidentata,and Fangfeng.The four Qi medicines used were mainly Wenand Ping,while the five flavors used were Gan,Xin,and Ku almost involving the twelve meridians.The spleen,lung,liver,and heart,resulting in 16 core drug pairs,The drug combination with the highest co-occurrence frequency is tangerine peel Pinellia ternata,Poria cocos Pinellia ternata,followed by Poria cocos licorice,and Atractylodes macrocephala ginseng;The combination with the highest confidence level is also tangerine peel pinellia ternata.Next are Baizhu Ginseng,Zhuli Pinellia ternata,and Fuzi Ginseng.Gather into the following 5 groups.Group 1:Acorus tatarinowii,Zhuli,Fangfeng,Gastrodia elata;Group 2:Achyranthes bidentata,Radix Astragali,Radix Ophiopogonis,Radix Astragali;Group 3:Angelica sinensis and Paeonia lactiflora;Group 4:Atractylodes macrocephala,ginseng,aconite,Poria cocos,licorice;Group 5:Pinellia ternata and tangerine peel.2.In the Chinese Pharmacopoeia,51 traditional Chinese patent medicines and simple preparations for stroke were included in this study,involving 236 Chinese medicines with a total frequency of 826,16 high-frequency medicines with a frequency of ≥ 11,and the highest frequency medicine was Chuanxiong,which appeared 28 times,accounting for 54.9%of the total frequency;The top 16 ranked next are Salvia miltiorrhiza,safflower,Angelica sinensis,borneol,earthworm,Gastrodia elata,red peony,musk,ginseng,Astragalus membranaceus,Panax notoginseng,kudzu root,bezoar,scorpion,and licorice.Although traditional Chinese medicine for promoting blood circulation and resolving stasis is commonly used,various types of traditional Chinese medicine are also commonly used,such as calming the wind and relieving spasms,aromatizing the orifices,and tonifying the deficiency.The four qi are mainly warm,calm,and cold,while the five flavors are mainly sweet,spicy,and bitter.The meridian tropism involves the liver,spleen,and heart,which are mainly involved in the twelve meridians.16 core drug pairs were obtained,with Chuanxiong Danshen having the highest frequency of occurrence and Scorpion Earthly Dragon having the highest confidence.And cluster to obtain 4 types of drug combinations.Group 1:Safflower,Chuanxiong,Danshen;Group 2:licorice,musk,borneol,and bezoar;Group 3:Gastrodia elata,red peony,earthworm,and scorpion;Group 4:Angelica sinensis,ginseng,Astragalus membranaceus,Panax notoginseng,and Pueraria lobata.Conclusion:1.In the treatment of stroke in ancient medical records,drugs such as resolving phlegm,calming wind,and tonifying deficiency are commonly used.The treatment focuses on regulating the spleen and lungs,dispelling phlegm and benefiting qi,and is combined according to the pathogenesis,course,and symptoms of the disease.2.The traditional Chinese patent medicines and simple preparations in the Chinese Pharmacopoeia is mainly used to treat stroke with drugs such as promoting blood circulation and removing blood stasis,relieving wind and spasms,aromatizing and opening orifices,and tonifying deficiency.The treatment focuses on promoting blood circulation and removing blood stasis,giving consideration to removing wind and dredging collaterals,opening orifices,and tonifying deficiency.3.In the treatment of stroke,ancient books and medical records put more emphasis on the product of resolving phlegm,and in the treatment of stroke,traditional Chinese patent medicines and simple preparations in the Chinese Pharmacopoeia put more emphasis on the product of promoting blood circulation and removing blood stasis;Both pay attention to tonifying qi and blood,adjusting yin and yang,in order to achieve a harmonious flow of qi and blood,and to balance yin and yang;The former focuses on the spleen and lungs to dispel phlegm and replenish qi,while the latter focuses on the liver to quell wind,clear collaterals,and stop spasms.