Clinical Observation On The Treatment Of Psoriasis Vulgaris (blood Dryness Syndrome) With Magui Siwu Granule

Objective:This study compared the clinical efficacy and safety of Maguisiwu Granules and Xiaoyin Granules in the treatment of psoriasis vulgaris(blood dryness syndrome),providing clinical application basis for the treatment of psoriasis vulgaris and the promotion and application of Maguisiwu Granules.Methods:From January 1,2022 to December 3 1,2022,100 patients with psoriasis vulgaris(blood dryness syndrome)who voluntarily participated in this clinical observation were selected from the outpatient department of the dermatology department of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine.They were numbered in order before and after their visits,and were equally divided into the treatment group and the control group according to random numbers generated by EXCEL,with 50 patients in each group.Both the treatment group and the control group were treated externally with Antiitching Moisturizing Lotion as the basic treatment.On this basis,the treatment group was treated with self-formulated Maguisiwu Granules,one dose per day,and taken warm twice in the morning and evening;The control group was treated with Xiaoyin Granules,3.5g/time,three times a day,and taken orally after meals.Before treatment and 4,8,and 12 weeks after treatment,psoriasis area and severity index(PASI)score,traditional Chinese medicine(TCM)syndrome score,dermatology life quality index(DLQI)score,adverse reactions during treatment,and related laboratory tests were observed and recorded in the two groups of patients.The clinical observation data were statistically analyzed using SPSS 25.0 statistical software.Results:A total of 91 patients completed this study,45 in the treatment group and 46 in the control group.After statistical analysis,there was no significant difference in gender,age,course of disease,PASI score,TCM syndrome score,and DLQI score between the two groups(P>0.05),which was comparable.Compared with the PASI score,TCM syndrome score,and DLQI score before and after treatment,P*was equal to 0.000,with statistical significance(P<0.05),indicating that both groups of drugs had curative effects.There was no significant difference in the PASI score between the two groups after 4 weeks of treatment(P>0.05),but P<0.05 after 8 and 12 weeks of treatment,which was statistically significant,indicating that the efficacy of the treatment group was better than that of the control group after 8 and 12 weeks of treatment.After 12 weeks of treatment,there was a significant difference between the two groups in TCM syndrome score and DLQI score(P<0.05),and the therapeutic effect of the treatment group was better than that of the control group.The total effective rate of PASI score in the treatment group was 8 6.67%,while the total effective rate in the control group was 78.25%.There was a significant difference between the two groups(P<0.05),and the therapeutic effect in the treatment group was better than that in the control group.There were no adverse reactions or events during the treatment.Conclusion:1.Maguisiwu Granules has good clinical efficacy in treating psoriasis vulgaris(blood dryness syndrome),and is superior to Xiaoyin Granules in improving the area and severity of skin lesions,alleviating TCM syndrome,and improving the quality of life of patients with psoriasis vulgari s;2.Magui si wu Granules has relatively good safety and are suitable for further research and promotion;3.The treatment concept of nurturing blood and opening sweat pores method has certain guiding significance for the treatment of psoriasis vulgaris(blood dryness syndrome),and can be further studied and promoted in clinical practice.