Observation On The Clinical Efficacy Of Modified Xiebaisan In The Treatment Of Bronchiectasis Complicated With Infection (phlegm-heat Obstructing The Lung Type

Purpose:By observing the clinical efficacy and safety of Jiawei Xibai Powder in the treatment of patients with bronchiectasis complicated with phlegm-heat obstructing lung syndrome,it provides an effective scheme for the treatment of patients with bronchiectasis by integrated Chinese and western medicine.Material and method:Eighty patients patients with bronchiectasis syndrome of phlegm heat stagnation were selected from the respiratory department outpatient department of Liaoning University of Traditional Chinese Medicine Affiliated Hospital from September 2021 to September 2022,who met the inclusion and exclusion criteria.Patients who meet the inclusion criteria were divided into an experimental group of 40 cases and a control group of 40 cases according to the order of their visits,using a random number table method.The control group was treated with conventional Western medicine for anti infection and phlegm reduction,while the experimental group was treated with Jiawei Xiebai San on the basis of conventional Western medicine for 14 days.On the first and 14 th days of the study,the total score of traditional Chinese medicine syndromes,single Chinese medicine symptom scores,inflammatory indicators(WBC,NEUT%,CRP,PCT,IL-6,IL-8),pulmonary ventilation function(FEV1% expected value,FEV1/FVC(%))were measured and recorded,respectively Record the BSI score(m MRC score,sputum culture results,bacterial colonization score,degree of lung involvement),as well as the levels of ALT and CREA.Apply SPSS26.0 to conduct statistical and analytical analysis of the data.Results:1.Before treatment,there was no significant difference in age,gender,course of disease and BSI score between the two groups,indicating baseline comparability.2.There was no significant difference between the experimental group and the control group in the total score of TCM syndromes and single TCM symptom before treatment(P>0.05);There was a significant difference between the two groups before and after treatment,with statistical significance(P<0.05).In the comparison between the two groups after treatment,the treatment effect of the test group on cough,expectoration,thirst,tongue pulse,blood in sputum,and constipation in stool was better than that of the control group(P<0.05),and the improvement of symptoms of cough,expectoration,thirst,and constipation in stool was more excellent than that of the test group(P<0.01),There was no significant difference in the improvement of fever symptoms between the two groups(P>0.05).3.There were no significant differences in inflammatory indexes(WBC,NEUT%,CRP,PCT,IL-6,IL-8)and pulmonary function indexes(FEV1% predicted value,FEV1/FVC(%))between the two groups before treatment(P>0.05).After treatment,the intra-group and inter-group comparisons were statistically significant(P<0.05),indicating that the experimental group was better than the control group.4.Before treatment,there were no significant differences in BSI grade,m MRC score,bacterial infection and degree of lung lobe involvement between the two groups(P>0.05);Before and after treatment,there were no significant differences in BSI grade and lung lobe involvement between the two groups(P>0.05).However,there were significant differences in m MRC score and bacterial infection reduction between the two groups before and after treatment(P<0.05),and the experimental group was better than the control group.5.ALT and CREA of liver and kidney function were not significantly different between the two groups before and after treatment(P > 0.05),indicating that this study had no adverse effects on ALT and CREA levels of patients.And no obvious adverse reactions occurred in both groups during the study.Conclusion:1 Jiawei Xiebai Powder can reduce the total and individual syndrome scores of traditional Chinese medicine in patients with bronchiectasis accompanied by infection and phlegm heat accumulation in the lungs,and alleviate the clinical symptoms of cough,expectoration,thirst,tongue and pulse,blood in phlegm,and constipation in stools in patients with bronchiectasis.Among them,the improvement of cough,expectoration,thirst,and constipation symptoms is particularly outstanding.2 Jiawei Xiebai Powder can improve patient lung function,improve dyspnea score,and improve patient quality of life;It can effectively eliminate colonized bacteria,eliminate pathogenic factors,and reduce the risk of exacerbation;It can improve patients’ inflammatory indicators(WBC,NEUT%,CRP,PCT,IL-6,IL-8),effectively control inflammatory infections,and reduce the risk of immune damage.3 During the study,the patient did not experience any adverse reactions,indicating that Jiawei Xiebai Powder is safe and effective.