Study On The Prescription And Medicine Rules Of Classical Prescriptions And Contemporary Prescriptions In The Treatment Of Complications Or Adverse Reactions After Intervention Of Ovarian Cance

Purpose:This study of traditional Chinese medicine treatment of ovarian cancer by western medicine intervention complications and adverse reactions(ADR)literature collection,refining a clear effect of the prescription,analyze the characteristics,further summarize the syndrome and related drugs,summarize the clinical use and drug addition and subtraction,and use the method of network pharmacology for the treatment of ovarian cancer(OC)abdominal pain possible targets,pathway and utility mechanism of molecular exploration,in order to provide a comprehensive understanding and reference for clinical subsequent application.Material and method:1.Taking CNKI,Wanfang database and VIP data as the source,we searched "TCM and Traditional Chinese medicine/Traditional Chinese medicine/TCM/Fang/soup" as the key word.The search period was to build the database to 2022.06.Then,the retrieved literature was classified according to different intervention methods,the "complications after intervention and ADR database" was established,the effective prescriptions were extracted,and the categories and characteristics of prescriptions were summarized.2."After ovarian cancer intervention complications and ADR database" into the literature,on the basis of screening the mentioned or card and clear or drug literature,to extract to use information,using the Excel table to establish "ovarian cancer intervention or drug information database",statistics involving the drug frequency,drug classification and frequency,summarizes the drug,and drug,analysis after OC intervention complications and ADR or card prescription rule.3.Through TCMSP platform screening angelica peony powder of drug effective active ingredients and target prediction,using OMIM,Genecards,TTD database for OC and abdominal pain disease targets,using Cystoscap software to build compound-target-disease network,drug target protein and disease target protein,then by GO analysis,KEGG pathway enrichment analysis,explore the treatment of OC abdominal pain possible molecular mechanism.Results:1.Ovarian cancer intervention complications and adverse reactions have 18,involving 170 articles(sorted by number):gastrointestinal reaction 55,bone marrow suppression 50,29,ascites 2823,immune decline,neurotoxicity 12,cancer pain 12,liver damage 9,hair loss,intestinal obstruction 6,4,menopause symptoms,diarrhea 3,blood viscosity increase 3,muscle joint pain 2,postoperative incision infection pain 2,and cold sweat,chemotherapy caused by amenorrhea,constipation each 1.The common adverse reactions include digestive tract reaction,bone marrow suppression,fatigue,neurotoxic reaction,and decreased immune function.Literature of therapeutic gastrointestinal response,involving 3176 cases,with a response rate between 51.2%and 100%,using 6 prescriptions and 9 prescriptions.Treatment of myelosuppression literature,involving 2995 cases,among which 8 clear effective rate documents,the number of cases was 260,the effective rate was between 53.5%and 96.9%,using 5 prescriptions and 9 prescriptions.Literature of treatment weakness,involving 1708 cases,among which 4 cases were clearly effective between 73.2%and 85.0%.The remaining 25 articles mentioned significant improvement of Karnofsky score or physical strength after treatment.The number of cases was 1289,using 1 prescription and 11 prescription.In the treatment of neurotoxic response,involving 945 cases and 5 clear effective rate,the number of cases was 314,the effective rate was between 61.11%and 96.43%,the incidence of neurotoxic response in the other TCM group was lower than the control group or better than the control group(P<0.05),2 prescriptions and 1 prescription were used.In the literature of therapeutic immune function decline,involving 1706 cases,7 cases with 491 cases,the effective rate was between 71.1%and 92.5%.The remaining 12 cases mentioned that the regulatory T cell level or improvement in the treatment group was better than that of the control group(P<0.05),1 cases and 2 cases were used.Common complications were ascites and intestinal obstruction:in the treatment of ascites,the number of cases was 1109,19 were clearly effective,between 57.14%and 95.56%,the remaining 4 articles significantly reduced the abdominal water after treatment,with 4 prescriptions and 3 prescriptions.In the treatment of intestinal obstruction,the total sample number of 142 cases,2 articles were clearly effective,between 83.3%and 90.3%.The remaining 4 articles mentioned the shortened recovery time of gastrointestinal function or the relief of abdominal pain,using 2 prescriptions and 3 prescriptions.2.Ovarian cancer surgery and(or)after chemotherapy or can have 25(by frequency order):nausea and vomiting 12 times,stay food less 8 times,constipation 7 times,pain,numbness 7 times,diarrhea,fatigue 6 times,6 times,abdominal distension 5 times,dry mouth 4 times,ascites,lump hard 3 times,3 times,3 times,anemia,fever 2,cough 2,other or can are 1 times(oral ulcer,mouth,mouth pantothenic acid,gum bleeding,urination frequency,less urine,hematuria,nausea,chills).Common or the syndrome(frequency 5):nausea and vomiting or the syndrome,use phlegm,cough and asthma medicine,qi medicine,specific high frequency drugs are pinellia pinellia,bamboo ru,tangerine peel.The distribution of four qi is both warm and cold,and the distribution of five flavors is mainly spicy,mainly lungs,stomach and spleen.In the occurrence of less dull food or rare syndrome,the often selected drug categories are digestion medicine,dampness medicine,and the specific high frequency drugs are divine comedy,hawthorn,malt,and chicken gold.The gas distribution is mainly warm and flat;mostly spicy and sweet;mainly spleen and stomach.When constipation or natural syndrome occurs,the often selected drug categories are laxative medicine and tonic deficiency medicine,and the specific high-frequency drugs are cistanche,hemp kernel and rhubarb.Four gases are mostly warm,flat and cold;sweet and bitter;large intestine,spleen and stomach.When pain or syndrome,the use of blood circulation and deficiency drugs,the specific high frequency drugs are Yanhusuo,white peony root,poppy shell.Four gases are mainly warm;bitter,spicy and sour;liver,spleen and lung.When numbness or normal occurrence occurs,the drug categories often selected are dispelling wind and dampness medicine,promoting blood circulation and removing blood stasis medicine,and the specific high-frequency drugs are mulberry branches,ox knee and papaya.The four gases are warm and plain;bitter and sweet;liver,kidney and spleen.In the event of diarrhea or natural syndrome,the often selected drug categories are astringent drugs and tonic deficiency drugs,and the specific high-frequency drugs are quixhiko and red stone fat.The gas distribution is mainly warm;the five flavors are sweet,bitter,sour,astringent,and the spleen,stomach,large intestine and lung.In case of fatigue or natural syndrome,multiple tonic drugs are used to balance the power of promoting blood circulation.The specific high-frequency drugs are chicken blood vine,psoralen,astragalus and dangshen.The distribution of four qi is mainly warm;the five flavors are mostly sweet and bitter;spleen,kidney and lung.In the event of sleepless or occurrence,the often selected drugs are calming drugs and deficiency drugs,but the specific high-frequency drugs are mainly safe drugs,including jujube kernel,Yuanzhi,Shouwuteng,acacia skin,etc.The four gases are mainly flat;mostly sweet and sour;mainly heart and liver.When abdominal distension or natural syndrome occurs,the drug categories often selected are qi drugs,deworming drugs,and the specific high-frequency drugs are wood fragrance,large abdominal skin,betel nut,etc.The distribution is mainly warm;spicy and bitter;spleen,stomach and large intestine.3.Pinellia pinellia-bamboo ru(frequency 5),Pinellia pinellia-tangerine peel(frequency 3),pinellia pinellia-ginger(frequency 3),three pairs of drugs often appear as nausea and vomiting or high-frequency drug pairs.Hawthorn-Divine Comedy(frequency 3)often appears as a high-frequency medicine for less food,and is often used with wetting drugs.Cistanche-hemp(frequency 3)often appears as a high frequency drug for constipation.Psoralen-blood vine(frequency 3)often appears as a high frequency drug for fatigue.Large abdominal skin-front car(frequency 3)often appears as a high-frequency drug pair of ascites.Eucommia ulmoides-ox knee-papaya(frequency 2)often appears as a high-frequency horn medicine for lower limb numbness;upper limb numbness is commonly used in mulberry branch-turmeric.4.Including white peony root,Atractylodes,Chuanxiong,Angelica,Poria and diarrhea,51 drug active ingredients,corresponding to 100 drug targets;4881 OC disease targets and 3839 abdominal pain targets.Six traditional Chinese medicines share 71 target proteins with OC and abdominal pain.The more active components are MOL000422(kaempferol kaempferol),MOL000358(beta-sitosterol β-sitosterol),MOL002135(Myricanone myriceone),and MOL000449(Stigmasterol myristerol C29H480).The signaling pathway plays anti-OC effects through IL-17 signaling pathway,MAPK signaling pathway,VE GF vascular endothelial growth factor signaling pathway,and PI3K-Akt signaling pathway.Conclusion:1.Guizhi,Astragalus,ginseng and rehmannia are the main treatments for ovarian cancer to promote blood circulation and promote qi.There are also some cases of these prescriptions,used in the treatment of digestive tract reaction,bone marrow suppression,ascites,cancer pain,decreased immune function,menopausal symptoms,increased blood viscosity,and constipation.Astragalus is used in neurotoxic reactions,liver and kidney damage,and alopecia to treat many weakness in ovarian cancer patients.Bupleurum prescriptions are used in digestive tract reactions,neurotoxic reactions and menopausal symptoms,mediating the Yang depression in ovarian cancer patients.Pinellia pinellia formula is used in digestive tract reactions such as nausea,vomiting and diarrhea to treat gastrointestinal symptoms caused by uncontrolled qi in ovarian cancer patients.The rhubarb formula is used to remove the stasis of ovarian cancer patients,and it is used in digestive tract symptoms,bone marrow suppression and intestinal obstruction.Rehmannia formula nourishes Yin and blood,and is used in liver and kidney damage and bone marrow suppression.Suite prescription warm Yang qi to benefit water,used in fatigue,ascites,postoperative incision infection pain.2.Different cases of ovarian cancer correspond to their respective drugs,but their medicinal properties are mainly warm,and most of the meridians are spleen,stomach,liver and kidney meridian,which may indicate that cold coagulation is another important pathogenesis of ovarian cancer,and may be related to Yang deficiency of spleen and kidney and blood stasis in liver and stomach.Including the same medicine for a variety of or syndrome treatment:phlegm cough asthma medicine used in nausea,vomiting,cough,qi medicine used in nausea,vomiting,abdominal distension,ascites,water wet medicine is used in less food,ascites,constipation,pain,diarrhea,fatigue,dry mouth,sweat,anemia,fever,blood stasis are used in pain,numbness,fatigue,lump,hard,astringent medicine is in pain,diarrhea,sweat are used.3.It may play the treatment of OC abdominal pain by regulating IL-17 signaling pathway,MAPK signaling pathway,VE GF vascular endothelial growth factor signaling pathway,and PI3K-Akt signaling pathway.