Correlation Between NLR, PLR And Other Indicators And Malignant Tumors With Lower Extremity Deep Vein Thrombosis And TCM Syndrome Analysi

Purpose: In this study,we analyzed the risk factors of malignant tumors combined with LEDVT by means of a retrospective study with case-control;analyzed the predictive value and clinical significance of neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)in patients with malignant tumors combined with LEDVT.To analyze the disease characteristics of patients with malignant tumors combined with LEDVT;to identify and analyze the characteristics of their TCM patterns;and to analyze the correlation between TCM patterns and relevant physical and chemical indicators.For better prediction,prevention and Chinese and Western medicine treatment.Material and method: Patients hospitalized in the Department of Oncology of the Affiliated Hospital of Liaoning University of Chinese Medicine from September 2021 to December 2022 were selected,and a total of 152 cases were included,among which those whose diagnosis was consistent with malignant tumor combined with lower limb deep vein thrombosis were included in the LEDVT group with a total of 76 cases,and control cases with the same cancer type and without LEDVT were screened into the control group with a total of76 cases in order to reduce the influence of the primary tumor type.We used Excel software to construct the patient case information database and SPSS 25.0 statistical software to statistically analyze the entered data,firstly,we compared the age,gender,PS score and tumor stage of the two groups,and then compared the blood routine indexes of the two groups after excluding the factors affecting the general data,and after analyzing the independent risk factors for the complication of LEDVT in patients with malignant tumors,we used the ROC curve to determine whether it could be The ROC curve was used to determine whether it could be used as a relevant predictive factor and to obtain the best cut-off value,and to further explore the influencing factors related to the high values of NLR and PLR.We also analyzed the disease characteristics of patients with malignant tumors combined with LEDVT,the distribution of TCM evidence patterns and the analysis of related factors.Results:1.In the control group,the mean age was 67.24±9.44 years;more females than males;PS score was mostly 2;tumor stage IV was common.In the LEDVT group,the mean age was70.09±9.91 years;more females than males;PS score was mostly 3;tumor stage IV was common;the top three primary foci of malignant tumors were lung cancer in 25 cases(32.98%),gastric cancer in 9 cases(11.81%),and 6 cases of ovarian cancer(7.89%).2.Thrombotic characteristics: There was no significant difference between the left and right distribution of LEDVT.Among them,19 cases(25%)had proximal deep vein thrombosis(DDVT)and 57 cases(75%)had distal deep vein thrombosis(PDVT),and the most common site of involvement was the intermuscular vein of the lower leg alone;the majority of patients had LEDVT more than 1 year after the diagnosis of malignancy(n=38,50%).3.Analysis of factors related to LEDVT: WBC value,NEUT value,NLR value and PLR value in the LEDVT group were significantly higher than those in the control group,and LYMPH count,RBC count,HGB count and HCT count were significantly lower than those in the control group,and the differences were statistically significant.4.Analysis of NLR and PLR independent risk factors: PLR value P=0.709 > 0.05,which cannot be used as an independent risk factor affecting the occurrence of LEDVT;but NLR value can be used as an independent risk factor affecting the occurrence of LEDVT,P<0.05. ROC curve suggests that NLR value can be used as an independent predictor of LEDVT in combination with malignant tumor.maximum NLR approx.The maximum NLR index was0.461,and the best cut-off value of NLR was 5.39.5.Analysis of factors associated with high NLR: There was a statistical difference between the high NLR group and low NLR patients in terms of TCM evidence and tumor stage(P <0.05).WBC count,NEUT count,LYMPH count,MONO count,D-Di count,CRP,and PLR values were statistically different in the two groups.6.Analysis of TCM evidence types and their associated factors: the distribution of the damp-heat infusion evidence type was the most,followed by the spleen-kidney-yang deficiency evidence type,with the least distribution of the blood stasis evidence type.The results of the analysis of the factors related to the type of evidence: the differences of WBC level,NEUT level and NLR level in the Damp-Heat Infusion evidence compared with the other 2 groups were statistically significant;the differences of MONO level in the Blood Vessel Stasis evidence compared with the Damp-Heat Infusion evidence were statistically significant.Conclusion:1.The distribution of TCM evidence of malignant tumor combined with LEDVT was predominantly damp-heat infusion evidence,and the levels of WBC,NEUT,and NLR were significantly higher in this evidence than in other evidence,and the levels of MONO were significantly higher than in blood vessel stasis evidence.2.NLR can be an independent predictor for the development of LEDVT in patients with malignant tumors.3.When LEDVT was diagnosed in patients with high NLR,the evidence type was more common with damp-heat infiltration evidence,and the tumor stage was more common with stage IV.High NLR was associated with WBC,NEUT,LYMPH,MONO,D-Di,CRP,and PLR levels.