Effectiveness And Safety Studies Of Cyadox In Broilers

Quinoxalines are synthetic antimicrobial agents with growth-promoting activity, and have been used extensively in food animals since 1970s. Olaquindox and carbadox are the well-known members, but they have been banned or strictly limited to use in food animals in some countries for their genetic or potential toxicities. It is necessary to develop a new drug of quinoxalines which can retain the good advantages of quinoxalines with less toxicity and more safety. Cyadox is a developing candidate. Some studies show that cyadox can promote the growth and improve the feed conversion in swine, sheep and fish with much lower toxicity than olaquindox. Hence, it is hopeful that cyadox would be developed as a replacer of olaquindox and carbadox with more safety and excellent effectiveness in growth promotion and antibacterial activity. Old quinoxalines are seldom used in poultry for their toxicities. Since cyadox is much more safer than the old drugs of quinoxalines, and early research had reported its growth promotion effect in poultry, it is possible for cyadox to be used safely and effectively in poultry. As a new drug for food producing animals, food safety is a key parameter to evaluate the application foreground, and has become a hotspot problem in the field of food science. Drug residue is one of the main factors to endanger food safety, while drug metabolism and residue depletion are the scientific groundwork to avoid drug residue. Therefore, metabolism and residue research is the organic composition in the exploitation of new drug for food animals. In this research, systemic studies have been carried out following the requirments of clinical evaluation in new drug research, which focuse on the safety, pharmacodynamics, pharmacokinetics and residue depletion of cyadox in broilers. The results clarified the effectiveness and safety of cyadox in broilers, and indicated that cyadox had a good application foreground in chicken production.1. The safety of cyadox in broilers. Cyadox at 1, 2, 4, 8 and 16g/kg b.w. levels were administrated orally to 30day old broilers to investigate the maximum tolerance dose(MTD) of chicken to cyadox. During 14 days after the administration, no obvious toxic effects were observed with no significant changes of daily weight gain and feed consumption(P>0.05). Hence, the MTD of chicken to cyadox was over 16g/kg b.w., which indicated that cyadox was a drug with no toxicity for chicken as the general toxicity guidline declares.Cyadox at 25, 50, 100, 200 and 500mg/kg levels were administrated in-feed to...