The Study Of The Preparation Of Superparamagnetic Iron Oxide And The Pharmacodynatics

With the rapid development of surgery, we want to get the better result from MR imaging, for example to find the disease with less area, and more accurately. It is more and more important to do some research on MR imaging contrast agents. The SPIO (superparamagnetic iron oxide) MR contrast agents have taken an important part in this field. This is partly because of its liver specification. The main part of SPIO is licked up by Kuffe's cells in normal liver. The tumor didn't contain these cells so SPIO concentration was lower in it. The difference between the normal and tumor can be detected in MR imaging. It brought about the new develop of diagnosis in combination cell fuction with MR imaging in liver limit cancer such as little and micro tumors. It was easier and rapider for the diagnosis procedure in liver disease. Besides this, USPIO (Ultrasmall Superparamagnetic Iron Oxide) contrast agents had a very potent future in so called magnetic labeled probe MR imaging. This probe would combine in some way with specific receptor, antibody and gene and go into the cell. The concentration of the magnetic cores inside the cell correlate with the material they could bind with. So the MR imaging signal represent the distribution of the receipt, antibody and gene. What we want to is to study several important factors in...