Studies On The Carbonylation Coupling Reaction Catalyzed By Palladium

The thesis consists of two parts:The first part is to summarize the development of coupling reaction catalyzed by palladium. The first section of this part summarize the wide application of coupling reaction catalyzed by Palladium in the confirmation of C-C and carbon-heteroatom bond. The coupling reaction involving Negishi Coupling reaction, Sonogashira Coupling reaction, Still Coupling reaction, Kumada Coupling reaction, Hiyama Coupling reaction, Heck Coupling reaction and Suzuki Coupling. The second section of this part is the review on carbonylative coupling reaction catalyzed by Palladium.The second part is our study on the synthesis of ferrocenylethynyl aryl ketones and2-Ferrocenyl-4H-chromen-4-ones. The first section of this part is the convenient synthesis of ferrocenylethynyl aryl ketones via Palladium-Catalyzed Sonogashira carbonylation coupling reaction. The reaction was performed in short time and in good yield using ethynylferrocene and ArI as the starting materials Pd(PPh₃)₄/CuI as catalyst, K₂CO₃ as base, toluene as solvent under CO (1 atm). The second section is the synthesis of seven 2-Ferrocenyl-4H-chromen-4-ones via carbonylation coupling-annulation catalyzed by Palladium for the first time. Ethynylferrocene and 2-iodophenol are used as the starting materials, Pd(PPh₃)₄/CuI as catalyst, K₂CO₃ as base. The reaction is performed under CO (1 atm) to obtain the objective products in short time and good yield. This synthetic procedure can be applied in the synthesis of flavonoids and chromones derivatives substituted by ferrocene.