Ultramicro-morphology And Membrane Molecular Biology Of Cysticercus Cellulosae And Effects Of Drugs

Cvsticercosis cellulosae is an important parasitic zoonosis endangering the health of human and development of pig breeding. No~~? the perfect prevention and therapy drugs still lack. The author studied firstly. s~tematicallv and roundly on the ultramicro-morphology and membrane molecular biolog~?of Cvsticercus cellulosae and effects of drugs during development in vitro and in vivo. The results ~vere showed as follo~vs.I The structure of the embryo membrane of Taenia .caginata eggs was defined firstlv.It was 4 layers including outer membrane laver(OML). vitelline layer (VL). embrvophone layer(EL) and oncospheral membrane(OM).and the outer layer was a fibre membrane to protect the eggs.2. The scolex with hooks of Taeina sagin ala oncosphere was dieovered firstly after cultured for 5 days.3 .The surface ultramicro-morphologv of Cvsticercus cellulosae was observed firstly. svstemticallv and roundly. It s found that its cervix microprocesses distributed endlong and that of the bladder cluster. The bladder was composed of two districts near the cervix and far from the cervix, and the micoprocesses of the district near the cervix distributed densenessly. The outward hole of the drainage system of sticercus cellulosae was discovered, and the hole was more in the district far from the cervix This indicates that the function of two districts is different.4.The structure of the bladder was defined firstly to be 6 layers. tegument (T). exteriormesenchvma (EM).parenchvma layer (PL).interior mesenchyma (IM),interior matrix zone(IMZ) and interior laver(IL).The structure of the cervix was 3 layers.tegument(T),mesenchyina(M)and Parenchyma(PL).YThe author studied firstly. svstemtically and roundh?on the membrane molecular biology of Citicercus cellulosae during development, and put forward the biomembrane system. chemical compose, the process of phosphorus metabolism and biomembrane characteristic. and their changes during development.6.The author selected the drugs against C. cellulosae and studied its mechanism of action on the ultramicro-morphology and membrane molecular biology level. The results showed NX1 was effective against immature and mature C.cellulosae. it inhibited the phospholipid metabolism of two stages.NX(, was only effective against mature C.celluIosaL? it damaged directly the structure of the scolex.NX~ was ineffective.7.The content of the serum SA of pigs infected by C. cellulosae can be used as an assistant index at early diagnosis.and also as a judging index on early therapy effect.Doctor:Hao Yan-hongTutor : Prof Li Qing-zhangMajor : Basic Veterinary...