| Purpose:To systematically evaluate the effect and safety of Jianpi Qutan method for adjuvant treatment for coronary heart disease.Material and method: China National Knowledge Infrastructure Database(CNKI), Wanfang Database, Chongqing VIP Database(VIP), China Biology Medicine Database(CBM), MEDLINE(Pubmed), and Cochrane Library were retrieved with the deadline on January 12,2016. The inclusion trials of CHD were Jianpi Qutan method together with basic treatment to basic treatment or placebo with basic treatment. The risk of bias of cochrane handbook and Rev Man 5.3 were conducted by authors. Sensitivity analysis was constructed by using two different effect models. Besides, a funnel plot was created to analyze potential publication bias.There was a random, multi-center, multi-blinded, placebo-controlled and superiority randomized trail. A total of 160 patients with stable angina pectoris were randomly assigned to two groups: a treatment groups and a control group. The treatment group received Chinese herbal medicine consisting of Yi-Qi-Jian-Pi and Qu-Tan-Hua-Zhuo granule,and conventional medicine. The control group received placebo medicine in addition to conventional medicine. All 2 groups undergoed a 12-week treatment and 2-week follow-up. We observed curative effect of TCM clinical syndromes, angina symptoms, improvement of abnormal ECG, Nitroglycerin, blood lipids(TG,TC,HDL-C,LDL-C,ox-LDL-C) and safety indicators.Results: 2267 patients from twenty-nine studies were included. Jianpi Qutan method for adjuvant treatment for CHD compared with the placebo with basic treatment group showed that: The result of cardiovascular events showed RR(95%CI) was 0.25[0.07, 0.87]; the result of TCM clinical syndromes showed RR(95%CI)was 2.09[1.62, 2.69]; the result of improvement of abnormal ECG showed RR(95%CI)was 1.18[1.00, 1.40]; the result of improving symptoms of angina pectoris showed RR(95%CI)was 1.48 [0.79, 2.78]; the result of cholesterol total showed MD(95%CI)was-0.14[-0.28,-0.00]; the result of triglyceride showed MD(95%CI)was 0.13[-0.04, 0.31]; the result of low-density lipoprotein showed MD(95%CI)was-0.18[-0.31,-0.05]. Jianpi Qutan method for adjuvant treatment for CHD compared with basic treatment group showed that: The result of improvement of clinical symptoms showed RR(95%CI)was 1.41[1.18, 1.69]; the result of TCM clinical syndromes showed RR(95%CI)was 1.33[1.23, 1.44]; the result of improvement of abnormal ECG showed RR(95%CI)was 1.31[1.21, 1.42]; the result of improving symptoms of angina pectoris showed RR(95%CI)was 1.23[1.16, 1.31]; the result of stopping and decreasing of Nitroglycerin showed RR(95%CI)was 1.17[1.03, 1.31]. Nine studies showed that treatment group was superior in lowering cholesterol total to that of the basic treatment group. Six studies showed that treatment group was superior in lowering triglyceride to that of the basic treatment group. Eleven studies showed that treatment group was superior in lowering low-density lipoprotein to that of the basic treatment group. Eight studies showed that treatment group was superior in improving High- density lipoprotein to that of the basic treatment group. One studies showed that treatment group was superior in improving Highdensity lipoprotein to that of the placebo with basic treatment group. Experimental group had 12 adverse reactions in 24 studies which described it. However, the symptoms were slightly or corrected after efficient treatment. They did not mention severe adverse reactions.The effect of TCM clinical syndromes, the effect of treatment group is 76.00%, the control group is 60.00%, a statistically significant differrence(P<0. 05).The effect of angina symptoms, the effect of treatment group’ s angina pectoris is 76.00%, the control group is 54.29%, a statistically significant differrence(P<0. 05). The effect of improvement of abnormal ECG, the effect of treatment group is 54.05%, the control group is 25.00%, a statistically significant differrence(P<0.05). The effect of Nitroglycerin, the effect of treatment group is 53.33%, the control group is 37.50%, no significant differences(P>0. 05). The comparison of blood lipids: The treatment group of TG, TC and ox-LDL-C were significantly decreased, the difference was statistically significant(P<0.05); The treatment group of LDL-C has a downward trend and HDL-C has a rising trend, but there were no statistically significant difference(P>0.05); The control group of ox-LDL-C was significantly increased, the difference was statistically significant(P<0.05); There was no statistically significant difference in the control group of TG, TC, LDL-C and HDL-C(P>0.05);The treatment group of TG, TC,LDL-C and ox-LDL-C were significantly decreased in 12 weeks after treatment compared with the control group, and the difference was statistically significant(P<0.05); The treatment group of HDL-C had no statistically significant difference in 12 weeks after treatment compared with the control group; The difference between before and after treatment in the treatment group of TG, TC and ox-LDL-C was statistically significant(P<0.05); The difference between before and after treatment in the treatment group of LDL-C and HDL-C was no statistically significant(P>0.05). The treatment group of safety indicators had no statistically significant difference in 12 weeks after treatment compared with the control group(P>0.05). In two groups there were not any serious adverse reaction before and after treatment.Conclusion: Jianpi Qutan method might have advantage in preventing or lowering the occurrence of cardiovascular events and case-fatality rate in CHD patients, releasing clinical symptoms, improving TCM clinical syndromes, improving the ECG of patients with CHD, improving the clinical effect of angina pectoris, reducing the use of Nitroglycerin, lowering blood lipid levels and reducing adverse reactions.
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