| Part l.The epidemiological study in middle-aged and the elderly peopleIn order to study the relationship among higher fasting serurn glucose (FSG), hyperlipemia,hypertension, hyperuricemia in middle aged and elderly people, FSG, triglycerides(TG), cholesterol(TC), uric acid (UA) and insulin (INS) of serum. blood pressure (BP) and body mass index (BMI)of l477 men and women over 40 years of age were analyzed. The results showed that: 1)The levelof FSG raised with the increase of the age. The relations between FSG and TC, UA, BP and BMIwere significant. The levels of TC, UA, BP and BMI in the abnormal FSG group were higher thanthose indices in the normal FSG group. There were positive relationships between FSG and TC, UA,BP;BMI, age, waist line and hip line. The factors related to FSG were age, BMI, TC and diastolicpressure by stepwise regression. 2) The total incidence of hypertension was 30.9%, and in whichisolated systolic hypertension (ISH) was l3.3%. Both systolic and diastolic blood pressures wereincreased with the age increasing. The levels of SFG, UA, BMI in hypertension group were higherthan those in normal blood pressure group, but the difference of serum TC between the two groupswas not significant. There were positive correlation between hypertension and SFG, TG, UA. INS,age as well as BMI. 3) The level of TG raised with the age and the hyperglycerides in 50~54 yearsold group reached the highest percentage and then decreased. The peak of TC was at 50~ and 55~years old groups. The body weight and height were also decrease with the age and the percentage ofBMI≥25 increased with aging. The mean measurements of blood pressure, body weight, BMI andUA of hypertriglycerotideamia group were higher than those of normal TG group as well. Theinteractive effects between bypercholesterolemia and ad the significant meaning. The factorsaffected TG were BMI, UA, TC, and diastolic blood pressure in turn. For TC, they were age, TG,FSG, body weigh and BMI. 4) The incidence of hyperuricemia was 8.7% in 40y~group, 13.5%in50y~, l8.5% in 60y~ and 22.4% in 70y~ group. The values of TG, FSG,BP,BMI and WL inhyperuricemia group were higher than those indices in normal UA group while there were nodifference in TC and HL between the two groups. The significant factors were TG, FSG, BP, BMI,age and WL with positive correlation. and their linear coefficients were 0.234, 0.127, 0.250, 0.202,0.236 and 0.28l respectively. Conclusion: the main risk factors of increased FSG for the middle-aged and elderly people were aging, BMI, TC and diastolic blood pressure.Part 2. The therapy effects of diet control and exercise on the patients with impairedglucose toleranceImpaired glucose tolerance (IGT ) is the prophase of type 2 diabetes mellitus (T2DM) and themost important high risk population of T2DM. The process of IGT developing to T2DM could beprevented by the intervention therapies effectively For evaluating the therapy effects of changinglife style, including diet control and exercise, on the patients with IGT we observed the differencesbefore and after the intervention. ll2 suspected patients, 54 male and 58 female, aged over 40 werechecked the oral glucose tolerance test (OGTT). They took 75g glucose after the fast venous blood7sample was taken out and 2 hours later, the venous blood sample was taken out again. Those who 2h blood glucose value were between 7.8mmo1IL-~-l 1. lmmollLwere the patients with IGT. The IGT patients were given health education, diet and exercise consulting, while their diets were investigated by dietary intake questionnaire. Each patient got a personal menu according to his/her age, gender, body weight and physical activity. They learnt how to use the food exchange method to arrange a balanced diet and how to increase energy expend by exercise. The patients were rechecked the OGTT and other blood biochemical index after 4 months intervention. The results showed that the patients' dietary pattern changed in 4 mo...
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