Study On Risk Factors And Susceptibility Genes In Ovarian Cancer

(Study on risk factors for ovarian cancer)Background: Ovarian cancer is one of the most common malignant tumors among women, and is the leading cause of death from gynecological carcinoma because of its very poor prognosis. Therefore, it is of great significance to control or reduce risk factors to prevent ovarian cancer from occurrence.Objectives: To investigate effects of risk factors in environment, social-psychological, hereditary aspects on development of ovarian cancer in Chinese women. To put forward some evidences on high-risk population protection and prophylaxis of ovarian cancer. Methods: 102 ovarian cancer patients and 204 controls, who were from the same or neighborhood district as cases, were interviewed with epidemiology and psychological questionnaires. The distribution of age, nationality and occupation was similar between the case and control group, and all subjects have been living in Tianjin at least 10 years. Data on demographic, menstrual, reproductive, contraception, personal disease history, family history of cancer, dietary habits and intake, psychological factors etc. was collected, and then, was analyzed with non-conditional logistic regression model.Results: Single-factor analysis results show that, early age at menarche and late age at first livebirth increase relative risk of ovarian105cancer. Odds ratio of menarche age is 0.7714 (95% CI 0.6418-0.9273), and OR at over 17yr is only half of that at below 13yr. Number of pregnancies, high parity, lactation, contraception are all decrease the risk of ovarian cancer, OR of which are 0.8317 (95% CI 0.7062 ?0.9796), 0.7122 ( 95% CI 0.4505-1.1260), 0.1612 (95% CI 0.0897-0.2895), 0.2893 (95% CI 0.1747 ?0.4789, respectively. Endometriosis is also associated with ovarian cancer, and OR is 8.5955 ( 95% CI 1.7906-41.2612) .Drinking tea, physical exercise is reversely correlated to ovarian cancer, while irregular defecation is positively related to the cancer. Among dietary factors, pork intake increase risk(OR=1.4528, 95% CI 1.0614?.9884) , on the other hand, intake of green leafs vegetables, mustard group vegetables, fruit have the contrary effects on ovarian cancer.Family history of malignant tumor appears strong correlation with risk ofovarian cancer, OR of which is 6.7375 (95% CI 2.8799-15.7625) .Andthe value of OR reaches 15.6374 (95% CI 0.7189-340.1709) whenmother and/or sisters suffered from breast/ovarian cancer.Results of social-psychological factors indicate that, depression, anxiety,suspicion, negative life events and high score of P, N are all associatedwith ovarian cancer. OR are 0.5190 (95% CI 0.3058-0.8816) ,2.6672(95% CI 1.0435-6.8145), 3.5000 (95% CI 1.4127-8.6718), 4.6789(95% CI 1.7112-12.7876), 2.2752 (95% CI 1.6464-3.1437), 1.2991(95% CI 1.0222-1.6497) , respectively.Multi-factors logistic regression analysis results demonstrate that, family history of malignant tumor, negative life events, high P score, irregular defecation are the major risk factors for ovarian cancer, OR of which are 7.1381 (95% CI 3.3269- 15.3155), 4.3897 (95% CI 1.6079- 11.9831), 3.1459 (95% CI 0.7998-12.3734), 2.6541 (95% CI 1.6854-4.1797) ;106while, high parity, lactation and intrauterine device are the main protective factors. The odds ratio are as following: 0.5189 (95% CI 0.4298-0.6264), 0.4914 (95% CI 0.3081 -0.7832), 0.2543 (95% CI 0.0966-0.6691) respectively.Conclusions: It is multi-factors including internal & external environment, social-psychology, and hereditary aspects that attribute to ovarian cancer. Some proposal is recommended to women:1) Mother-self breast-feeding2) Take contraception measure3) Reasonable dietary pattern: decrease intake of red meat, increase intake of vegetables and fruit4) Do physical activity usually5) Keep mind open and happy6) Periodic surveillance on women who have cancer family history...