| To study the effect of bone marrow cells on myocardial regeneration, angiogenesis, myocardial basic structure and cardiac function after its implantation into the acute myocardial infarct site in F344 rats. The results showed: at first, 2nd, 4th week after implantation, bone marrow cells with fluorescent had been observed in the implant sites. A portion of the implanted cells had differentiated into myogenic cells. The regenerating myocardial cells had been observed by electron micrographs and connected with the host myocardium through intercalated discs. The infarct size was significantly smaller in cell implant group than that in the control group. Meanwhile, the implanted bone marrow cells could secreate a variety of cell factors such as bFGF, IGF-1, TGF-61, IL-1B and IL-8, which induced angiogenesis and promoted collateral circulation in the infracted myocardium. The ischemic myocardium showed signs of preservation of the basic structures of the infracted myocardium and also the recovery of heart function eventually. The present study provided the potential application of the bone marrow cells in the treatment of myocardial disease.
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