The Exploreing Study Of Growth And Genesis Of Uterine Leiomyoma

Objective: Uterine leiomyomas are the most common pelvic tumors, occurring in one of four women, and they represent the single most common indication for hysterectomy. The genesis and growth-promoting factors responsible for their development are poorly understood. We speculate that growth hormone -insulin-like growth factor-I axis may play a role in the initiation of these tumors. We evaluated the circulating GFU IGF-K IGFBP-3 and ovary steroids to investigate whether GH-IGF-I axis secretion in women of leiomyoma varies over the menstrual cycle, and relation to the growth of leiomyoma.Methods: Using sampling were obtained in 41 of leiomyoma women during the 21 of follicular and 20 of luteal phases of the cycle. Select of 40 normal women during the 21 of follicular and 19 of luteal phases of the cycle as contrast. The fasting serum GH, IGF-I, IGFBP-3 were measured by IRMA method and E2, P, T were measured by RIA method on each occasion.Results: There were no differences in GH, IGF-I, IGFBP-3 of level in two phases of the cycle. However, the leiomyoma patents had less concentration of GH. IGF-I, IGFBP-3 than contrast groupin the secretary phase(p<0.01), and lower IGFBP-3 than contrast group in the proliferous phase. There was decrease but was not statistically significant in E2, P of the leiomyoma patents. But the testosterone was significant declined than contrast group in the proliferous phase. There were negative correlations between IGF-I and age and positive correlations between IGF-I and IGFBP-3. There were positive correlations between E2 and P and T, and a negative association between E2 and age in normal women. However, there were no correlations between T and E2 or T and P and in leiomyoma women, also there were no correlations between E2 and age. But there were positive correlations between GH and IGFBP-3 or GH and P or GH and E2.Conclusion: We concluded that the effect of changes in the ovarian steroid on the GH axis depended on ages. The concentration of GH, IGF-I, IGFBP-3 decreases with aging, and ovary steroids also decline as well as reciprocal regulation by estradiol on the GH axis. GH, IGF-I play an important role in immunity, the lower immunity to tumor maybe adapt to the growth and genesis of uterine leiomyoma.