An Investigation On Treating Subinvolution Of Uterus New Drug Of Puji Gongtai Keli

The articles select title from'An Investigation on treating subinvolutjon of uterus new drug of Fuji gongtai keli', the prescription is summary of clinical practice of famous doctor of traditional Chinese medicine in a long time, after the related specialists (in Peking ,Tianjin ,Liaoning etc.) demonstrating ,the drug is affirmed sufficiently and evaluated highly. In the course of study .according to the technical claim of examination and approval method of new drug which was issued by State Drug Demonstration, technological process, quality standard and pharmacodynamics related to function and use were studied in order, all technical data of materia medica that need before clinic were finished. Combining demand of new drug and the title, technique optimization and quality standard of king drug were made a deep study.1.Studies of technological process :On study of technological process according to the feature of big dose ,we defmited drug granules as the form of the new drug .according to the physical and chemical properties , technological process was optimized according to the result of the orthogonal experiment and pharmacological experiment ;accessories , flavour enhancer and condition of coming to form were optimized ,and feasibility of AB-8 resin applied to purify mixture preparation wasdiscussed.2.studies of quality standard : Both white peony root and motherwort herbs were chosen to quantitative determination in standard .Precision ,reappearance ,stability, rate of recovery etc conformed to related measure in studies of methodological inspection . we defmited TLC identification method for white peony root ,dodder seed ,barbary wolfberry fruit ,chinese angelica ,root bark of Chinese wolfberry . quality standard and draft clarification of fingerprinting of Dodder seed, king drug, were recommended . HPLC fingerprinting and RAPD technique were made a deep studies in identification of dodder seed and its confused species.3.studies of pharmacodynamics :according to function and use of this prescription ,we had engaged in these studies of uterine smooth muscle ,anti-mflammatory ,analgesic and hemostatic ,which provided experimental basis for clinical application.In short, through studies of technological process, quality standard-and pharmacodynamics ,it can be certificated that technique of the new drug is stable ,quality standard is controllable , effect is reliable.