| Coronary heart disease (CHD) has been the first critical disease of human being around the world. Percutaneous coronary intervention (PCI) has established an effective procedure for CHD. However, there were still some problems contributed to intervention related sever complications such as acute occlusion and restenosis pre- and pro-procedure.Since Ross initiatively suggested that atherosclerosis be a chronic inflammatory disease of the vessel wall in 1973, there have been progressive reports about the relations between inflammatory activation and coronary atherosclerosis. Recent data indicate that percutaneous transluminal coronary angioplasty (PTCA) can elicit an activation of inflammatory responses; preprocedural plasma C-reactive protein (CRP) level appear to be an independent predictor of complications and late restenosis in patients with PCI. However, CRP as a marker of inflammatory response cannot reflect the initial mechanism of inflammation and the relation between the inflammatory cells and the cytokines. Furthermore, the predictive value for clinical outcome or the guidance for prevention of complications was no precise. Lately study revealed that Interleukin-8 (IL-8), a powerful regulator of immunology and inflammation, is a mediator for the inflammation evoked by the tumor necrotic factor (TNF)> interleukin-1 and interleukin-6. The major bioactivity of IL-8 is as an attractant activating neutrophiles to secrete adherent factors, further eliciting the up-graduation of ?2-integrin Mac-1 (CDlib/CD 18) on neutrophiles. IL-8 is believed a key factor during the cascade of coagulation factors and cytokines. Therefore, The consistent studies on theregulations of IL-8 and other cytokines in patients with coronary heart disease pre- and pro-PCI were performed. The relationships between IL-8 and the early complications, the predictive value of IL-8 for late cardiac events and restenosis, the expression of IL-8mRNA on monocytes after PCI were all concerned. The results were as follows:1. The dynamic changes of IL-8 in patients with coronary heart disease pre- and pro-PCIThe study group comprised 121 consecutive patients who underwent PCI , The pre- and post-procedural level of plasma IL-8, CRP, Vascular endothelial growth factor (VEGF), Von Willebrand factor (vWF), CD lib/CD 18 on neutrophiles and the expression of GPlIb/IIIa (CD41) on platelet were examined to investigate the interaction between them.The results obtained as follows. (1) Before PCI, the Plasma level of IL-8 was enhanced in patients with unstable angina pectoris (UAP) than those in patients with stable angina pectoris (SAP) and those in controls (all PO.05), CRP, vWF, CDllb/CD18 and CD41 showed the same trend; The plasma level of IL-8 in UAP patients with complex lesions (type C) was significantly higher than those with type A and B (both PO.05). (3) The plasma level of IL-8 in UAP group increased to peak level 203.4?1.82 pg/ml at 12 hours post- PCI (PO.01), and as while an increase of vWF to peak level 257.7?0.35%, and CD41 to peak level 234.2?5.21(MFI) at 4 hours (both PO.01), CDllb/CD18 and CD41 to peak levels 453.2?5.22(MFI) respectively at 24 hours (P<0.01). (4) There were a significant correlation between the peak levels of IL-8 and CDllb/CD18 in UAP (r=0.747,?=0.002), and also showed the same trend of platelet CD41 and vWF (r=0.881, ^=0.031), IL-8 and CRP(r=0.795, ^=0.002).The results above-mentioned indicated that there was systemic inflammatory response evocated by IL-8 in patients with CFfD before PCI, which was correlated with the extent of coronary atherosclerosis and the stability of lesion. IL-8 and the interaction between IL-8 and abnormal activation of coagulation system during the procedural of PCI further elicitand enhance the inflammatory response.2. The evaluation of IL-8 changes in CHD patients with early complications pre- and pro-PCIThe pre- and post-procedural level of plasma IL-8 was examined in 121 consecutive patients who underwent PCI to investigate the prognostic v...
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