| Diabetic microangiopathy is mainly complication in diabetic mellitus, seriously affects the health of human being. It is hard to define on conception, for almost whole tissues and apparatus in body are implicated, including retina, kidney, nerves, muscle and derma et al. Among these, it is especially important for diabetic nephropalhy (DN) and diabetic retinopathy (DR). The typically pathological change is the disturbance of microcirculaton, microvessel neoplasia and hyperplsia of microvessal.the mechanism of diabetic microangiopathy is very complicated. Usually, the chronic high level blood glucose is regarded as the necessary factor. But it need more evidence to prove, on other word, only high level blood glucose can not be sure to deduce diabetic microangiopathy. All factors could be divided into tow aspects: one relation with high level blood glucose, such as hyperinsulinism, hypertriglyceridism et al; the other not close to high level blood glucose, including obesity, hypertension, and heredity.As more and more research show heredity is quite important factor which deduce diabetic microangiopathy. Although with dispute, the angiotensin conversing enzyme (ACE) gene in RAS system is mostly related to diabetic microangiopathy. There are three genotypes in ACE, divided accord to amplificied product fragment, only 190bp corresponding to II; 490bp to DD: both 190bp and 490bp to D/I. ACE gene is relation with the level of blood ACLi and complications of diabetic mellitus, as many research reported. But there is still opposed view. Most scholars agree that DD genotype in ACE gene is relation to diabetic microargiopathy.Although no define name about diabetic microangiopathy in Chinese medicine, it has be known that complications are easy deduced by chronic diabetic mellitus (called xiaoke disease in TCM). And the clinic symptom, pathogeny as well as pathology of xiaokc disease are recorded. Except resemblance between diabetic microangiopathy andxiaoke disease, there are still respective characters. Recently many scholars have reported the close relation between diabetic microangiopathy and blood stasis syndrome ot'TCM. There is not a standard uniform of syndrome differentiation type' (SDT) about diabetic microangiopathy in TCM, and the xiaoke disease' SDT are consulted. The accepted standard include the guidance on principle of clinical research of Chinese new drug issued by sanitation ministry, the teaching material of TCM and academy' standard. Among them, the standard issued by sanitation ministry is abroad adopted for it' briefness, authority and easy using.The research about relation between SDT of TCM and some objective indicator are getting more, such as insulin release correlation with SDT et al. But it is seldom reported the relation between gene polymorphism and SDT. With the progress of modern biological technology, it has been cognized that the factor of gene together with circumstance deduces disease. In TCM'inornate theory, a disease is the result of 'inner factors'and 'outer factors', similar with the modern medicine concept. In fact 'inner factors' are more emphasized in TCM. Thereby, it may be the best point for conjunction TCM and modern machine that study of SDT at gene' view.In TCM' theory, 'tizhi', which refer to individual character of function and construction during glowing and ageing, is more emphasized. This kind of character determines susceptible to certain disease. Syndrome type refer to survey of a certain pathological phase during disease developing, which is the common effect of 'xie' and 'zheng'. Thereby, in theory, syndrome type is correlated with gene. The main purpose of this research is to find weather exist a relation between syndrome type and 2 type diabetic mellitus.In this research, the clinic epidemiological survey is adopted, and 120 2 type diabetic microangiopathy patients are enrolled as observed group , 66 2 type diabetic mellitus as control group. Following the standard issued by the sanitation ministry, all patients are grouped 3 primary syndrome t...
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