Effect Of Kunningan On ER,ERmRAN And Neurotransmitters In Hypothalamus Of Pms Rats

In the paper, through animal experiments in which animalmodels of perimenopause syndromes are made, and with advancedtechniques, such as optic microscopy, electronmicroscopy, redioimmunoassay, biochemistry, in situ hybridization, the compositemechanism closely reIated to the happening, development,prognoses and trend later on of PMS are studied at the cellular andmolecular level, so that the mechanisms of how the kunninganconcentrating pill can play an in f1uential role in prevention andtreatment of PMS can be deep1y probed into.The results shown that'l. The animal mode1s are successfully copied since they'revery familliar to the very nature that perimenopause in human ownsdetected by examination of sex hormones level.2. Kunningan concentrating pi1l can enhance estrogenbioactivity by raising the level of ER and ERmRNA in the targetorgan iz ati on.3 .Kuningan concentrating pill can increase D -EP level inhypothalamus of PMS rats, which may be connected with theappearance of hectic fever and metabo1ism of neural transmitter incentral nervous system.4.Kunningan concentrating pi1l can regulate function ofmonoamine neurotransmitter and their ratio in hypothalamus in PMSrats, decreased level of 5-HT, inproved level of Ne, adjustedvegetative nerve function. suggesting that dysfunction ofhypothalamus neurotransmitter may be one of results in low sexgl and.5 .Kunningan concentrating pill can restrain flee redical3$tsil op tei!jXPy I$t,Y:{gi2xdamaging organism, while postpone senility by ameliorating freeredical metabolism, increased the activity of SOD and GSH-PX,decreased MDA.The research results shown that Kunning an concentrating canplay a treatment PMS role through synthetically mechanism, keephomeostasis. and so much so that, kunningan concetrating pillbecome a compound agent of TCM with a brilliant prospect.