| Chinese Herb Nephropathy (CHN), being a not well defined notion, was put forward by European and American medical colleagues. The reason for some of Traditional Chinese Medicines (TCM) not being allowed to be imported by foreign countries is mainly that these medicines may cause kidney damages. These medicines include: Fourstamen stephania root, manchurian dutchmanspipe stem, slender dutchmanspipe root, LongDanXieGan Pill, oral drug prepared liquid for gallstone, and scores of other TCM and traditional Chinese patent medicines. They all have Aristolochic acid (AA) as one of the components.There have been correlated reports nationwide focusing on LongDanXieGan Pillï¼caused kidney damages in recent years, and attentions have been aroused in all aspects. Deep researches into the mechanisms of drugsï¼caused kidney damage and its countermeasures can help safeguard clinical medication. In 1993, Vanherweghen in Belgium reported: 70 out of 105 female patients got renal failure and required kidney transplants or dialysis after 1 to 3 years' using antiobesic (components include: Phenfluoramine, Amfepramone, Cascara, Belladonna extract, Acetazolamide, Fourstamen stephania root, Officinal Magnolia Bark) which contains TCM components. The antiobesic is a mixture of both Chinese and Western, botanic and chemical medicine, and Phenfluoramine, Amfepramone were known to cause renal damages. However, some of the foreign scholars believed kidney failure was mainly induced by TCM, and the incident was so called "CHN". In September 1999, two female patients from Britain were reported to have renal failure 2～4 years after taking TCM containing manchurian dutchmanspipe stem to treat eczema. They had to receive kidney transplants or dialysis. So US,Britain, Japan, Spain, Austria, Egypt, Philippines, etc. one after another banned selling and using these drugs for the reasons mentioned above. Lots of studies in China have been carried out aiming directly at the practice of foreign physicians using medicines containing TCM. Studies focused on manchurian dutchmanspipe stem and its component AA. Results showed that manchurian dutchmanspipe stem or AAï¼caused renal toxicity correlated positively with dosages and medication time. Clinical medication of TCM is based on dialectic, according to the nature of the drug, following the principle of drug compatibility, the compound form rather than single drug or single component can be applied by clinic. The main principle for drugs prescription is to enforce the action, reduce the toxic and side effects, and determine the doses under stipulated dosage. These are quite different from the medication methods reported to be renal toxic in foreign countries. However, it doesn't mean TCM are free of toxicity and side effects. According to TCM nature theory, toxic drugs are less harmful when they are used in combination with other compounds than they are in single usage. The present study aims to determine whether compounds of TCM are based on modern science. We have chosen two compounds both containing manchurian dutchmanspipe stem as examples in experiments and compared them with single dose drugs. We want to know whether there are differences in manchurian dutchmanspipe stemï¼caused renal toxicity between its single dose and its compound form, and where the difference originates. Our study will provide experimental data for scientific compound compatibility of TCM.1 Renal toxicity effect of manchurian dutchmanspipe stemObjective:To observe the effects of single dose manchurian dutchmanspipe stem on renal function, morphology of renal tissues Immunohistochemistry, terminalï¼deoxynucleotidy1 transferase mediated dï¼UTP nick end labeling (TUNEL) were used to observe correlated the influence of manchurian dutchmanspipe stem on epithelial cells of tubules.Methods:â‘´ Acute renal toxicity by manchurian dutchmanspipe stem.SD rats were divided randomly into control group (A group) and manchurian dutchmanspipe stem group (B group, including low B1, middle B2, high B3 dose...
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