Cordyceps Mycelium Powder With Chronic Aristolochic Acid Kidney Damage Prevention And Treatment Of The Role Of Experimental Research

To establish a model of chronic aristolochic acid nephropathy (CAAN) in rats and to investigate the pathogenesis of its renal interstitial fibrosis include alleviate its renal injury by Chinense Caterpillar fungus mycleium powderIn the biochemical researches, Wistar rats were distributed into fourgroups. Groupl was normal control ,Group 2 and 4 were model control, 3 treated group. Group 2 was received Aristolochia manshuriensis Kom. decoction 10g/kg body weight ,Group 3 was received Aristolochia manshuriensis Kom. decoction lOg/kg and Chinense Caterpillar Fungus mycelium powder 5g/kg body weight once daily for 8 weeks. Group 4 was subcutaneous injected aristolochic acid lOmg/kg body weight once daily for 8 weeks . After administration ,urine samples were obtained for NAG, β₂-MG and protein evaluation.It was found that body weights in group 2 , 3and group 4 were decreased compare with group 1. Protein of 24 hours urine, NAG and β₂-MG of the two groups were higher than groupl ( P<0. 05, P<0.01 ) . There for , the results of study suggest that Aristolochia manshuriensis Kom.decoct ion and aristolochic acid could result in tubulopathy. We also found that rats of Chinense Caterpillar Fungus mycelium powder treated resulted in improved body weights, Protein of 24 hours urine, NAG and β₂-MG at eight weeks point compared with Group 2 that rats were received Aristolochia manshuriensis Kom. decoction 10g/kg. There for , the results of study suggest that we need more times to make model to confirm the function of Chinense Caterpillar Fungus mycelium powder on alleviating the renal injury of chronic aristolochic acid nephropathy (CAAN).In the histological researches , tubulointerstitia1 histological points. Transforming growth factor β₁ (TGF-β ₁), Tissue inhibitor of metalloproteinase-1 (TIMP-1) and Matrix metallo proteinase-9 (MMP-9) were determined.It was found that in the group 2, 3and group 4 the tubulo -interstitial histological points increased compared with those of the normal control (P<0. 01 ) , and the points of group 4 was the highest, while the group 3 had the lowest ones . the...