| Background and ObjectiveQuantitative Sensory Testing (QST) is a innovative psychophysical technology to quantitatively determine the sensory of patients, can evaluate the sensory disturbance quantitatively. It is now two decades since the publication of the first clinical paper on the use of quantitative sensory testing disorders (Fruhstrofer et al., 1976), and the field has seen a flurry of subsequent publications. As the reader will note, most clinical situations which affect sensory function have been investigated by means of QST. In most instances, the data is predominantly descriptive, consisting primarily of abnormality rates for various modalities of sensation. Yet, in the major disorders of sensation, such as those associated with Diabetes mellitus, QST research has gone far beyond basic description. Here the use of QST in the clinic is much better defined, including its role in diagnosis, staging, longterm follow-up of the natural history of disease, and determination of treatment efficacy. Data is also available regarding the relative role of QST versus other parameters of neural function, such as electro-physiological and autonomic testing.Testing thermal and vibration modalities enables assessment of the different types of sensory fibres. Vibration stimuli, peripherally, activate large myelinated fibres (A() and centrally, the dorsal columns. For the thermal senses, peripherally, cold sensation is mediated by small myelinated fibres (A(); warm sensation by unmyelinated warm specific C-fibres; heat-pain by small myelinated and unmyelinated nociceptors and cold pain—both types of thermal stimuli (nonpain and painful) activate the spinoreticulothalamic tracts.Sensory threshold measures are the most commonly employed QST parameter. Being psychophysical responses, QST parameters are very sensitive to different methodological aspects of the test, thus, considerable attention must to paid these details in order to obtain valid and reproducible results. Many studies, particularly when the technique was initially introduced, did not follow strict experimental protocols. As a result, contradictory findings may be encountered in the literature. Additional methodological issues, important in threshold determination, include site of testing, pressure of stimulator application, stimulator size and subject training. QST was applied clinically in pain assessment, metabolic neuropathies, toxic neuropathies, acquired diseases, autonomic failure, occupational medicine and evaluation of medications.Mao si zhong applied QST in clinic in 1998 in china. She evaluated the application of QST to diabetic peripheral neuropathy, Guillain Barre syndrome and polyneuropathy. She consided QST was a sensitive method for diagnosis of diabetic neuropathy. Chen da wei used thermal quantitative testing to identiy whether or not there are sensory deficits in postherpetic neuralgia (PHN) patients and obtain information about the magnitude of thermal sensory deficits and its relationship with the painful intensity in PHN patients, and discussed multi-mechanisms in different PHN patients. Objective: Experimentally investigate the QST characteristic of special crowd, to extend the usage of QST.MethodsUsed TSA-II (Thermal Sensory Analyzer) tested the cold sensation, warm sensation, cold pain and heat pain plus to sensation of viberation for the health elders and patients with disorders such as anxiety neurosis, chronic alcoholism, tuberculosis treatment, sciatica, peripheral facial paralysis, and analysed the contributing factors and discussed the probable mechanism of those phenomena. There are six main parts: 1. Investigated the QST characteristic of elders and discussed the determinate contributing factors, to determine the feasibility of using QST methods in diagnosing the peripheral neuropathy of elders. 2. Investigated the QST characteristic of patients of anxiety neurosis, compared with the characteristic of diabetes patients, and then gave the effect of anti- anxiety neurosis t... |
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