Experimental Study Of The Action And Mechanism To Asthma Model And The Compatibility Of Suzi Jiangqi Decoction

Bronchial asthma is one of the important chronic diseases that seriously harmed the healthy of public in the world at present.Its etiological factor is various,pathogenesis is complicated.Airway nonspecific inflammation and air hyperreactivity(AHR) are the main character of this disease.The dissertation presents the research summarize progressed on the etiological fators,pathogenesis,and the most recent treatments of bronchial asthma from the TCM documents and the medicine documents.The infiltration of EOS and the imbalance of Th1/Th2 cytokines have the key action to the episode ,pathogenesis and persistent of bronchial asthma.Suzi Jiangqi decoction,a effective prescription to bronchial asthma in clinic,could keep the inspired air going downward and dispell phlegm,and warm the kidney to help inspiration to relieve asthma.By establishing asthma model and selecting some indexes closely related to airway allergic inflammation, studying and discussing deeply the action and mechanism of Suzi Jiangqi decoction.By the decomposition and compatibility's study,reseaching the action and mechanism of the method of keeing the inspired air going downward and dispelling phlegm and the method of warming the kidney to help inspiration to relieve asthma to asthma model and studying deeply the sence of compatibility of the two methods in the therapy of bronchial asthma.In the experimental studies,on the level of entirety,cytokine,inflammatory factor,histomor and gene,by means of pharmacology,pathlolgy,immunoradiometry andimmunohistochemistry,studying the action and mechanism of Suzi Jiangqi decoction to asthma model and the significance of compatibility of the two methods.Results:Suzi Jiangqi decoction can improve obviously the respiratory function of the asthma model and control obviously the airway inflammation.The mechanisms relate to restraint EOS'chemotaxis,promoting EOS'apoptosis and Th1/Th2 cytokines' regulation,and TNF, NF-B, ICAM-1 and ET's regulation.It could control obviously the passage recombination.The mechanisms probably relate to TNF- , ET's regulation.It could reduce AHR. The mechanisms relate to control the airway inflammation.Conclusion: Suzi Jiangqi decoction has the actions ofanti-mflarnrnatory,immunoregulation,reeducing AHR and control the passage recombination. The two methods all have the action of anti-inflammatory and immunoregulation.But, the method of keeing the inspked ak going downward and dispelling phlegm is more obviously than the method of warming the kidney to help inspiration to relieve asthma on the action of anti-inflammatory.The latter is obviously on the action of immunoregulation.In the pathogenesis of bronchial asthma, the airway inflammation and immunologic imbalance influence each other.So,by the action of anti-inflammatory,the method of keeing the inspked ak going downward and dispelling phlegm enhances the action of immunoregulation of the method of warming the kidney to help inspkation to relieve asthma. By the action of immunoregulation,the method of warming the kidney to help inspkation to relieve asthma can enhances the action of anti-inflammatory of the method of keeing the inspked ak going downward and dispelling phlegm. Suggestion: the significance of compatibility of the two methods reflects on the action of anti-inflammatory and the action of immunoregulation.