| In this investigation, polybutylcyanoacrylate was used as the drug carriers, and the model drugs selected was mitomycin C, magnetic fluids (MF) was used as magnetic materials. The colloid solutions of mitomycin C-polybutylcyanoacrylate magnetic nanoparticles (MMC-PBCA-MNPS) have been prepared at pH=6.3~6.5 by emulsion polymerization method. The effects of growth inhibition of different concentrations of MMC-PBCA-MNPS, PBCA-MNPS and MF and MMC were investigated on normal human liver cell strain (L-02 cells) in vitro, and distributions and targeting tropism of Fe3O4 and MMC of MMC-PBCA-MNPS colloid solution injection was examined in vivo of mice. Its targeting therapeutic effect in vivo was studied in nude mice transplanted subcutaneously by Bel-7402 cell lines.In the second chapter, Decanoic acid-coated Fe3O4 nanoparticle water-based magnetic fluids have been synthesized by chemical coprecipitation of Fe2+ and Fe3+ ions existed in microemulsions with ammonia water. The influences of stirring time, volume of acetone, volume of water and mass of used decanioc acid on the formation of Fe3O4 nanoparticle magnetic fluids have been examined. The particle size and size distributions etc., of obtained magnetic fluids have been determined by photon correlation spectroscopy (PCS). On basis of the above-mentioned results, we have designed and prepared some decanoic acid-coated Fe3O4 nanoparticle water-based magnetic fluids. The results indicated that average diameter is 10~20nm for the decanioc acid-coated magnetic particles. The value of saturation magnetization of themagnetic fluid was 1.85 kA m-1.A one-stage method of preparation, which was not yet reported in literatures, has been reported for bilayer surfactant stabilized Fe3O4 water-based magnetic fluids. Using decanoic acid as surfactant, decanioc acid stabilized Fe3O4 water-based magnetic fluids were prepared by the above-mentioned one-stage preparation method. These obtained water-based magnetic fluids have been characterized by photon correlation spectroscopy (PCS), TEM and JDM-3 type magnetometer. The solid samples were prepared for the monolayer decanioc acid-coated Fe3O4 magnetic particles and bilayer decanoic acid-coated Fe3O4 magnetic particles. The composition and properties of two solid samples were investigated by IR, TG, DTQ DSC(at 10~600C, -10~80C). The experiment results indicated that decanoic acid-coated Fe3O4 water-based magnetic fluids were stable periods of one year as evidence by a lack of observable phase separation. Their stability was compared favourably with one of bilayer decanoic nonanoic acid-coated water-based magnetic fluids prepared by a two-stage method.In the third chapter, a new method was put forward and established to prepare the colloid solutions of PBCA magnetic nanoparticles at pH =6.3-6.5 aqueous medium, for the first time. The colloid solutions of PBCA magnetic nanoparticles were prepared at pH=6.3~6.5 by emulsion polymerization method. The particle size, size distributions, polydispersity etc. have been determined by photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM). Iron content was determined by UV-spectroscopy. It has been given that the influence of concentrations of BCA and Dextran-70 on the particle size and size distributions of PBCA magnetic nanoparticles. The determined Iron content showed that the major of Fe3O4 nanoparticles of magnetic fluids were enwarpped by PBCA. The stabilization mechanism of colloid solutions of PBCA magnetic nanoparticles was discussed. The best preparation conditions were selected by the orthogonal design experiment. The colloid solutions of mitomycinC polybutylcyanoacrylate magnetic nanoparticles have been prepared at pH=6.3~6.5 by emulsion polymerization method. The particle size, size distributions and saturation magnetization of obtained colloid solutions were determined by photo correlation spectroscopy (PCS), transmission electron microscopy (TEM) and JDM-3 type magnetometer. The embedding ratio, drug loading and Fe-content of magnetic nanoparticl...
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