The -148C/T Polymorphism Of β-Fibrinogen Gene And Plasma Fibrinogen Levels In Young Adults With Ischemic Stroke

Objective Fibrinogen is related to cardiovascular disease was widely accepted. However, It is uncertain whether the -148C/T polymorphism of B-fibrinogen gene is related to plasma fibrinogen levels and ischemic stroke.The aim of this study is to investigate the relationship between -148C/T polymorphism of B-fibrinogen gene and plasma fibrinogen levels in young adults with ischemic stroke. A brief review was also made in discussing the pathogenesis of Fibrinogen and B-fibrinogen gene as the vascular risk factors.Methods 69 young patients with ischemic stroke and 60 young healthy individuals were enrolled in this study. The B-fibrinogen gene -148C/T polymorphism was analyzed by PCR-RFLP, and plasma fibrinogen levels were obtained from prothrombin time assay.Results Plasma fibrinogen levels of patients with stroke are significant higher than those of healthy controls(p<0.01). In both groups those with T allele have higher plasma fibrinogen levels than those without(p<0. 01), but there is no significant difference in T allele frequencies between patients and controls(p>0. 05). Among the smoking patients, those with T allele have higher plasma fibrinogen levels than those without it (p<0.05), but it made no significant difference between somoker and nonsmoker.Conclusion High plasma fibrinogen level is an independent risk factor for ischemic stroke in Chinese young adults. Plasma fibrinogen level is influenced by -148C/T polymorphism of B-fibrinogen gene. Together with other risk factors and environmental factors, T alleleexerts its influence on increasing the level of plasma fibrinogen and may be a heritable risk factor for ischemic stroke in young adults.