The Roles Of The Chemokines In Celiac Metastasis Of Serous Epithelial Ovarian Carcinoma

Objective: The celiac metastasis is a major lethal cause. To reveal chemokines mediating the celiac metastasis of epithelial ovarian carcinoma by way of investigating the chemokine receptor expressions in serous epithelial ovarian carcinoma cell lines and tissues, and the corresponding ligand expressions in membrana abdominis.Methods: The RT-PCR was applied in chemokine receptor expression in serous epithelial ovarian carcinoma cell lines and tissues. According to arranging in the receptor expression level order, high-expressed chemokine receptors were chosen for further investigation. Analyzing expression of corresponding chemokine receptors and their ligands in serous epithelial ovarian carcinoma tissues with immunohistochemical, and analyzing expression of the ligands in peritoneum and endometrium tissues.Results: 1 Two kinds of Chemokine receptors - CXCR4, CXCR6 are high-expressed in serous epithelial ovarian carcinoma cell lines. 2 Expression of CXCR4 is very high in serous epithelial ovarian carcinoma tissue, and CXCR6 is high-expressed, also. 3 The ligand of CXCR4, SDF-1 is high-expressed in serous epithelial ovarian carcinoma and peritoneum tissue, but low-expressed or non-expressed in endometrium tissues.Conclusions: SDF-1, which is high-expressed in serous epithelial ovarian carcinoma and peritoneum tissue, may contribute to metastasis of ovarian carcinoma. Study of chemokine receptors and their ligands may give us someproof by which we can search a new approach to hold back metastasis of serous epithelial ovarian carcinoma.