| Systemic Lupus Erythematosus (SLE) belongs to autoimmune disease and the cause of SLE is still uncovered, many facters,such as genetics, sexormones, environment, medicine, infection, immune reaction and so on, to be concerned, of which the genetics is most decisive and inherent factor. The genetic constitution together with medicine, infection, immune reaction and environment factor,will cause SLE and aggravate the illness. Young woman suffers from this disease easily and has nine times as many as man in probability. Its recurrence rate is high and it can damage human organs and systems then threaten health and life seriously. In China, SLE morbidity is between from 20 to 70 per100,000, which is still climbing up day by day.Many scholars have various views about cause and pathomechanism of SLE, such as exogenous factors theory , internal injury theory and internal and external factor theory. We conside that clinical manifestation of SLE is complex and multiplex so internal and external factor theory is most consonant to reason and comprehensiv;the irregulation of Yin and Yang is the immanent cause of SLE coming on, the exogenous factors is the requisite qualifications for the coming on, kidney vacuity and stasis toxin is the key to the pathomechanism of SLE, and supplementing yin and clearing heat and toxic is the baisic method of treating active SLE. The research status of SLE manifests hat treatment of SLE by TCM integrating with west medicine has good perspective. â… , ObjectiveWe observed the clinical theraputic effect which Ziyinglangchaung capsule treated active SLE, and probed into the mechanism of treatment on the levels of mRNA. II, Methods( I )Trail designing and case selecting: Perform random, controlled, open observation-treatment design. On the basis of the uniform diagnosis, bringing into, elimination criteria and syndrome differentiation criteria of TCM. In this study, 40 active SLE patients were at random divided into TCM group(20cases, treated by Ziyinglangchaung capsule integrating with west medicine) and control group (20cases, treated by glucocorticoid) <> The 2 groups have no significant difference in the syndrome differentiation, age, gender , SLAM disease active scales and TCM syndrome or symptom complex scales (P >0.05) . (II)Therapeut i c MethodsThe control group is treated with prednisone in the dosage of lmg. kg~'d~' and its dosage is reduced according by the state of SLE. The TCM group patients take five Ziyinglangchaung capsules each time , thre time per day in addition. (HI)Observing and treating period and index3months. We observed the clinical therapeutic effect of Ziyinglangchaung capsule treating active SLE, and the effects on SLEDAI disease active scales, and TCM syndrome or symptom complex scales, reducing corticorsteriods dosage , GC index, ESR, urine protein, renal function, PBWC GC and GRmRNA. (IV)Effect-determination standard: Established in accordance with the 3rd edition of Clinical-guiding Principles on New Chinese Medicine. (V)Statistics processing: t~test, rank sum test, by statistical software SPSS13.0. IE-. Results(I )TCM group is signficantly superior to the control group in the total effectiveness rate (90%of TCM group is higher than 80% of control group). And... |
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