Clinical Study On TCM Syndromes Of Chronic Gastritis

This　project　 was　funded　by　Beijing　Natural　Science　Foundation(No.7032014)　and　Beijing　Municipal　Science　&　Technology　Commission　(No.954812700)　,　mainly　studying　on　TCM　syndrome　distribution　law　and　the　influencing　factors　in　chronic　gastritis(CG).Meanwhile,　we　inquired　further　into　the　neuroendocrine　and　immune　regulation　of　the　stomach　mucosa　in　different　syndromes　of　deficiency,　deficiency　with　excess　and　excess　.　This　paper　contains　mainly　epidemiological　investigations　and　clinical　trials.　　Chronic　stomach　disorder(CSD),belonging　to　Stomachache,　Distension　and　Distress,　and　etc.　in　TCM,　is　a　common　and　frequently　gained　disease　in　which　CG　and　peptic　ulcer(PU)　are　most　common.　With　the　invention　of　proton　pump　inhibitor(PPI),　cases　of　PU　decreased　remarkably　while　the　incidence　rate　of　CG　remains　high.　Therefore,CG　was　chosen　as　our　investigating　object.　Firstly,　applying　 the　method　of　 modern　epidemiology　and　mathematical　statistics,　we　strictly　designed　the　prospective　large-sample　observation　on　960　cases　of　CG　and　studied　primarily　the　law　of　syndrome-distribution,　the　characteristics　of　symptom-distribution,　and　the　relationships　among　syndrome-distribution　and　symptoms,sex,　ages,　seasons,　addictions　to　diets,　smoking　or　alcohol,　and　Helicobacter　pylori(HP),　etc.　Secondly,　the　syndromes　of　deficiency　of　spleen&　　stomach,　spleen　deficiency　with　phlegm-wetness,　and　wetness　-heat　in　spleen　&　stomach,　which　are　commonly　occurred　in　different　developing　stages　in　the　one　disease,　were　chosen　as　observation　targets.　Through　applying　the　techniques　of　pathology,　radio-immunology(RI)　and　immunohistochemistry,　etc.,　and　integrating　TCM　and　modern　medicine　theories,　local　stomach　mucosas　of　the　patients　with　the　syndromes　from　deficiency　to　excess　were　extracted　toi　nvestigate　the　regulating　modes　ofg　astrin(Gas),　calcitonin　gene　related　peptide(CGRP)　and　T　lymphocyte　subgroups　.　The　results　and　conclusions　are　as　follows:　1. Results　of　the　observation　on　the　law　of　syndrome-distribution　declared　that　the　incidence　rate　of　the　discordance　between　liver　&　stomach　syndrome　ranked　first　among　the　syndromes　of　CG,　followed　by　liver　stagnation　with　spleen　deficiency,　deficiency　of　spleen　&　stomach,　wetness　-　heat　in　spleen　&　stomach,　and　deficiency　of　stomach-yin　syndromes.　The　incidence　rate　of　the　discordance　between　liver　&　stomach　syndrome　accounted　for　51.0%,　stagnation　of　liver　with　spleen　deficiency　for　18.8%,　liver　stagnation　related　liver　&　spleen　and　liver　&　stomach　syndromes　together　for　69.8%,　and　the　others　for　30.2%.　It　indicated　the　variances　in　the　syndrome-distribution　of　CG　whose　mainstream　changed　from　spleen　&　stomach　related　syndromes,　such　as　the　deficiency　of　spleen　&　stomach,　wetness　-　heat　in　spleen　&　stomach,　tot　he　liver　stagnation　related　liver　&　spleen　and　liver　&　stomach　syndromes.　　2. Results　of　the　symptom　spectrum　showed　that　among　the　14　most　frequently　appeared　symptoms　in　the　960　cases,　most　symptoms　occurred　more　than　500　times　were　related　to　liver　stagnation;　and　those　occurred　more　than　300　but　less　than　500　times　related　to　spleen　dysfunction.　Mathematical　statistics　proved　that　modern　chronic　stomach　disorder　mostly　correlated　with　liver　and　spleen.　Also,　our　study　indicated　initial　surveys　of　the　distributions　and　the　incidence　rates　of　the　symptoms　in　different　syndromes　in　CG,　and　established　the　foundation　of　further　study　on　standardization　of　syndrome　based　diagnosis　and　treatment.　　3. Results　of　the　relationship　between　syndrome-distribution　and　ages　revealed　that　CG...