The Pharmacodynamics Experiment And Mechanism Study On Treatment Of Diabetic Coronary Heart Disease By Tangguankang Capsule

Based on reviewing systematically the literature and data on diabetic coronary heart disease from ancientry to modern times,According to the new pathogenesis of Prof. Lidelin,diabetic coronary heart disease is caused by qi-yin deficiency, blood stasis and phlegm stagnation. The basic therapeutic method was supplementing qi, nourishing yin, activating blood and dissipating phlegm accordingly. Recipe Qixuanyixin had been applied in clinic for a long time and had got satisfied curative effect. In order to reach Qixuanyixin's curative effect and mechanism,we made systematically reach on ratsThe resultsof study showed:(l) Recipe Qixuanyixin could lower blood-glucose, glycosylated serum protein and blood-fat; it can distinctivly improve myocardial ischemia which made by posterior pitutary injection and cardie function;it can decrease free of myocardial enzyme.;(2) Recipe Qixuanyixin can increase activity of Na~+-K~+-ATPase which in myocardial cell membrane of the model rats;(3) Recipe Qixuanyixin can increase prin positive expression which in myocardial ischemia;(4) Recipe Qixuanyixin can do the same thing as potassium channel openner and can increasely open ATP Sensitive potassium current which can protect myocardium.