Age-related Differences In Post-infarct Cardiac Rupture And Early Remodelling Associated With MMPs Expression

Objective: Cardiac rupture is the most dramatic and severe complication of acute myocardial infarction (AMI), which is mainly responsible for in-hospital death. The clinical trial had indicated that older age (>65years) is a independent risk factor of post-infarct cardiac rupture, however, the mechanism of age-related differences in post-infarct cardiac rupture is not clear. Recent studies on mice with surgically induced acute myocardial infarction (MI) have documented the frequent occurrence of ventricular rupture. This paper address whether age-related differences in MMPs expression, using different age mice to establish the AMI model, might raise the incidence of left ventricular rupture after myocardial infarct and explore the mechanism of age-related differences in post-infarct cardiac rupture.Methods: (1) Both male and female C57BL mice, aging at 3 and 12 months, were randomly divided into four groups: aged myocardial infarction group (12-mo-MI, n=70), aged sham-operation group (12-mo-SH, n=20), young myocardial infarction group (3-mo-MI, n=70), aged sham-operation group (3-mo-SH, n=20). AMI was induced by coronary artery occlusion and animals were monitored for fatal events. Sham-operated mice underwent similar surgery without occlusion of the LCA. We have examined the natural history, echocardiography, hemodynamic and histopathology in mice with AMI to detect effect of age-related...