| Senescence is a normal and complex life process that involved various organs and systems, and also an unavoidable physiological phenomenon with aging. Population aging will be a social problem along with the development of medical science and increasing of aging people. How to improve the living quality of aging people will be an important problem. The theory of"immune-nerve-endocrine network"was presented by Basedovsky in 1977. In 1988, Meites advanced that immune-nerve-endocrine network play an important regulating role in aging. Hypothalamus-pituitary-gonad axis (HPG axis) is a very important ingredient in the network, so it is imperative to investigate anti HPG aging agents. Cell senescence is implemented by signal transduction pathways among which Rb and p53 are extremely important. Products of tumor suppressor gene, such as Rb,p16INK4,p53,p19ARFand p21Cip1 protein occupy the core of two aging pathways. The preventing and delaying aging effects of Pine Pollen were investigated in this study from morphology, hormone, gene and protein aspects using modern cell biology and molecular biology techniques. Our study will provide experimental bases for choosing anti HPG aging traditional Chinese medicine.Part one Effects of Pine Pollen on anti-oxidative ability in serum of D-gal aging ratsObjective: To study the effects of Pine Pollen on anti-oxidative ability in serum of D-gal aging rats.Methods(1) Establishment of the animal aging model and groupsâ‘ Establishment of the aging model:120 eight-week male SD rats (SPF degree, weight 180200g) were used in this study. D-gal (dissolved by physiological saline into 5% solution) was injected into the rats, abdominal...
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