| Objectives: Ovarian cancer is the most lethal gynaecological malignancy, the origin of epithelial ovarian cancers, which constitute 90% of ovarian cancers. the lethality of ovarian cancer is primarily attributable to the advanced stage of the disease at the time of initial diagnosis, approximately 70~80% of patients present with disease that has spread beyond the ovaries. Despite advances in cytotoxic therapies, only 20~30% of patients with advanced-stage ovarian cancer survive 5 years after initial diagnosis. But the survival rate of patients diagnosed in early stage can reach up to 90%. Therefore, an understanding of the molecular mechanisms that regulate the motility and invasive behaviour of ovarian cancer cells has the potential to have a significant impact on the outcomes for this devastating disease. ovarian cancer has characterastics of insidious onset and rapid aggravation. the peritoneal and retroperitoneal lymph nodes are predilection sites of metastasis of epithelial ovarian cancer. Cancer cells adhere to peritoneal mesothelium, implant and inform metastasis. Finally the patient may die of extensive transfer to omentum, gastrointestinal tract, liver, spleen and so on. The invasion and metastasis of ovarian cancer are the most important influencing fators to success or failure of treatment. The metastasis of tumors is a complicated process including multiple steps and factors. So it has an important significance to investigate the metastasis and invasive mechanism of epithelial ovarian cancer, and can provide new methods and targets for treatment. Recently lysophosphatidic acid (LPA) has been paid more attention in research of gynecological tumors, especially for ovarian cancer. It exits in ascites and plasm of patients at high concentration. LPA is a small molecular lipid functionally related with growth factors. Its signal pathway plays many biological functions mainly through protein G couple receptor including...
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