Study On The Associations Of The Tubulointerstitial Lesions With Clinical Indices In IgA Nephropathy

Objectives: IgA nephropathy (IgAN) was first described in 1968 and is now recognized as the commonest primary glomerulopathy.The long-term outcome was initially thought to be benign but several series have reported highly variable prognosis with up to 20～30% of patients with IgAN developing end-stage renal disease (ESRD) within 20～25 years of diagnosis.The histologic grading system is useful to compare biopsy specimens and to predict the natural course of disease in IgA nephropathy (IgAN), although none of grading system is perfect. Firstly,The purpose of this retrospective study over a period of 6 years 678 renal biopsies was to investigate the relationship of the histologic grading, tubulointerstitial lesions(TIL) and clinical,laboratory data. secondly,To study the expression of connective tissue growth factor(CTGF), the phosphorylaed p38 Mitogen-Activated Protein Kinase (p-p38MAPK) Mediates TGF-β1–Induced Fibrogenesis in renal tissues of patients with IgA nephropathy. and theirs relationship with different grade tubulointerstital lession (TIL).Thirdly,To investigate the relationship of imbalance of T cell subpopulations and pathogenesis, clinical manifestation, as well as TIL of IgA nephropathy in prospective and controlled trial. Finally, To probe the effects of astragalus injection (AI) on renal tubular function in patients with IgAN and analyze the relationship of the renal tubular function (urinary retinol binding protein,RBP;N-acetyl-β-D-glucosaminidase,UNAG) and the severity of tubulointerstitial lesion. In order to further investigate the pathogenesis and preventional measure of IgA nephropathy.Methods:1. Study on the associations of the tubulointerstitial lesions with clinical indices in 678 cases of IgA nephropathyThe clinical,laboratory and histopathological data in 678 patients with...