| Hepatocarcinoma is the third leading cause of death in China, resulting in more than 120 thousands deaths per year , occupying over 45% of the total deaths hepatocarcinoma-resulted in the world, the second leading mortality of all the cancers. With a rapid increasing of the mortality hepatocarcinoma-resulted, therefore, the prevention and treatment on hepatocarcinoma in China looks very important.Selenium (Se), an essential trace element and normal constituent of diets, has been shown to have chemopreventive potential by a converging body of evidence from epidemiological, experimental, and clinical studies. Many papers have demonstrated that the protective effects of Se on cancer were strongly influenced by Se form. With the rapid increasing of morbidity of the cancer, more and more importance has been paid to the chemopreventive potential of selenium shown. In China, about 70% of the territory is short of Se, people there suffer form Se deficiency which is no benefit to health. In recent years, epidemiology dates indicate that Se deficiency shows positive correlation with tumor occur. Therefore, effect and mechanism study of Se on tumor has become an important problem.In this experiment, Se-enriched malt and sodium selenite were used as selenium sources, and their effects on the progress of hepatocarcinogenesis in SD rats were compared. At the same time, the mechanisms of selenium anti-hepatocarcinoma, including mechanism of neuro-endocrine-immunity, cell cycle and angiogenesis were also discussed.Test 1 Determination of the selenium content in selenium-enriched malt by hydride generation atomic fluorescence spectrometryA method has been developed for the determination of selenium in selenium-enriched malt by hydride generation atomic fluorescence spectrometry. The optimum conditions for the determination and the effects of digest reagents on digestion of samples and the...
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