The Feasibility Of Biodegradable Rapamycin-coated Stents For Prevention Of Restenosis In Miniswine Coronary Model Background

The Feasibility of Biodegradable Rapamycin-coated Stents for Prevention of Restenosis in Miniswine Coronary ModelBackgroundDespite important advances in the clinical use of coronary artery stents, restenosis is still an important limitation to its long-term effect. The main mechanism for post-stenting restenosis is neointimal proliferation. Drug-coated stent is the breaking-through progress in prevention of restenosis in these years. The on-going clinical trials showed that drug-coated stents might eventually solve this problem. The drug-coated stents used in these trials are nonbiodegradable. We havn't seen any report about biodegradable drug-coated stent.In the present study, we investigated (1) the histocompatibility of polylactic acid-coated stents and (2) the safety and efficacy of rapamycin-coated stents on the neointimal proliferation in miniswine coronary model. First part of this shudy:Thirty two polylactic acid-coated stents and bare metallic stents were delivered into the left anterior descending arteries and right coronary arteries...