Changes In Myocardial Collagen In Mice With Coxsackievirus B3 Myocarditis And Assessment Of Its Relativity To Cardiac Function

The cases clinically diagnosed as viral myocarditis have been increasing recent years in China. Instead of rheumatic myocarditis, viral myocarditis has become the most common myocarditis which seriously threaten human health, especially in adolescents and children. A feature of viral myocarditis is the cardiac diastolic dysfunction at the chronic stage. However, the molecular mechanism for this remains unclear. Recent studies suggested that pathologic expression of myocardial interstitium, particularly type I and III collagen may be an important reason for cardiac dysfunction. And some literatures suppose that the proliferative remodeling of cardiac interstitial collagen network during viral myocarditis is responsibe for cardiac diastolic dysfunction.But there is no experimental evidence to support the hypothesis so far. In order to illustrate the role of myocardial fibrosis in the pathogenesis and development of VMC, and its relationship to the cardiac function alteration, Coxsackievirus B3 myocarditis models were established, and using the models, the following studies have been done:(1) the myocardial collagen expression and its relation to the cardiac function in the VMC mice from the acute stage to chronic stage;(2)the changes in myocardial collagen expression and the cardiac function in the VMC mice at each stage intervened with losartan,an AII receptor antagonist;(3)the relationship...