2'5' Oligoadenylate Synthetase Roduced By The Human Hepatoblastoma-Derived Cell Lines HEPG2: Biologic Feature And Clinical Application

2'5' Oligoadenylate synthetase (2'5'AS) is generally an interferon-induced enzyme and is crucial for the anti -virus activity of interferon. But for the other biological effects of ioterferon, such as regulating immunol function, inhibiting cell mitosis and tumor cell growth, the exact mechanism of interferon-2'5'AS system remains to be indentified.In the present study,a series of experimental and clinical investigations were conducted to further look for the mechanisms of antivirus and anti-neoplasm action of interferon-2'5'AS, and to explore the possible pathogenesis in course of viral hepatitis, cirrhosis, hepatocellular carcinoma.Part I. Biologic features of 2'5'AS produced by HepG2 cell linesUsing cultured HepG2 cells, the basal activity of 2'5'AS in cells was assayed and compared in different cell lines. The effects of interferon, anti-interferon and...