Experimental Studies And Preliminary Clinical Applications Of Transcoronary Chemical Ablation

A study was done on chemical ablation with ethanol in the treatment of ventricular tachycardia (VT) in experimental animals and two patients. Epicardial ice mapping was performed with a probe to localize the site of origin of VT induced by programmed stimulation in 26 dogs 4 ～ 16 days after experimental acute myocardial infarction.In 20 of 33 episodes, a specific area where cooling with the ice probe terminated the VT could be found.Late diastolic activity was recorded from 3 of 6 such sites. The data presented suggested that the mechanism responsible for VT was reentry. After 0.3 ～ 1.2m1 of 95% ethanol was injected into a small coronary artery supplying the arrhythmogenic area, VT was no longer inducible in 10 of 14 dogs. Intramyocardial ethanol (1 ～ 3ml) was injected into the site of origin of VT in 9 dogs. In six of these, VT could not be reinduced. After injection of 0.4～ 1.2ml of 95% ethanol into a small normal coronary artery in 18 dogs, the changes in ECG, CK-MB and pathology werefound to be related to the dose of...