Nonrandom Chromosome Changes In Human Esophageal Cancer

In order to detect the early chromosomal change of esophageal epithelial cells during carcinigenesis and to determine whether esohpageal cancer cells have consistent chromosomal abnormalities, cytoge(?) (?) '(?)re performed on 26 previously untreated primary (?) cancer (EC) by using short-term culture method . G-banded chromosomes were analyzed both of cancer cells taken from the tumor itself and of the epithelial cells from the normal part of the esophageal mucosa . Of 26 cases, the two kind of cells were analysed in 11 cases, the cancer cells were analysed alone in 6 cases and the normal epithelial cells in 9.The results revealed that most of the cancerious and normal cells were near diploid. The chromosomes most frequently involved in the structural abnormalities were 1, 2. 3, 11 and 17 , occuring in 14 , 12, 15, 7 and 13 of the 26 cases respectively. Although the pattern of chromosomal aberrations were complex, the most frequent rearrangement breakpoints were found at 1pll-1p22,1q11-1q24, 2q11,3p14-21, 11q11-21 and 17q11~21.Those nonrandom rearrangement breakpoint may be associated with the activation of specific oncogenes and the loss of suppressor genes which are critical for the carcinogenesis of esophageal epithelium.The karyotypic changes of the n(?)r(?)at epithelial cells are very similar to those of the cancer cells ,...