Relationship Of Epstein-Barr Virus And T Cell Lymphoma

Malignant lymphoma is a common disease. In China, the incidence of T cell lymphoma comprise 34% of non-Hodgkin's lymphoma, which is much higher than in Western populations, and in keeping with the reports from Japanese. Epstein-Barr virus (EBV) is a tumor virus, which infects the vast majority of the world's adult population. In 1988, Jones et al first demonstrated the presence of EBV genomes in the tumor cells of CD4~+ peripheral T cell lymphoma in three patients with chronic EBV infection. T cell lymphomas are increasingly reported to be associated with EBV in various parts of the world. In 1999, Huh et al reported that EBV was detected in 58% of peripheral T cell lymphomas (PTL) by using in situ hybridization for EBV encoded small RNA (EBERs), and in angiocentric lymphoma (AL), the incidence is up to 92%. In order to clarify the relationship of EBV and T cell lymphoma, we performed the following three experimental studies.