Chemical Study On Medicinai Plants From Aquilegla (Ranunculaceae) And Discussion About Chemosystematics Of Tribe Isopyreae

This doctoral dissertation deals with the chemical and pharmacological researches on two medicinal plants from Aquilegia genus (Ranunculaceae), Aquilegia ecalcarata Maxim. and A. oxysepala Trautv. et Mey.. According to the morphology and phytochemistry studies on Tribe. Isopyreae, chemotaxonomy, phylogenetics and phylogenetic relationships within this taxa have been discussed. In addition, the distribution, folk curative effects, chemical constitutents of the tribe, and the distribution in plant, biological activities of oxoaporphine alkaloids were reviewed in the paper.Thirty natural compounds have been isolated from the ethanol extract of whole herb of A. ecalacrata for the first time. On the basis of physiochemical properties and spectroscopic analyses, their structures have been determined. Six of them were novel natural compounds, named as follows: Aquilediflavone â…  (21), Aquilediflavone â…¡ (22), Aquiletone (30), Aquilequinolone (31), Aquilegidine (33), Aquilegactam (43).Twenty known compounds (1~20) have been obtained from the ethanol extract of whole herb of A. oxysepala for the first time, five of them were identified as alkaloids and eight as flavonoids.Pharmacological tests of some compounds from A. ecalcarata revealed that 9 and 29...