Application Of Radionuclide Techniques In Evaluation Of Dilated Cardiomyopathy And Ischemic Cardiomyopathy

PurposeBoth dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (CAD-CM) may have similar clinical presentation. The differentiation of DCM from CAD-CM is important since prognosis and treatment of the two diseases are different. The ^99mTc-MIBI myocardial perfusion SPECT, ¹⁸F-FDG myocardial metabolic PET imaging and radionuclide ventriculography were performed in 83 patients (pts) in order to assess the clinical significance of radionuclide techniques in differentiating DCM from CAD-CM.Materials and methods83 pts with cardiomegaly (UCG: diameter of left ventricle >55mm) and ventricular dysfunction (NYHA: II -IV) were studied and divided into two groups. Group A included 28 pts with DCM ( 23 male and 5 female, aged 32-76 years, mean 53.6 ± 10.4 years). Diagnostic criteria were (1) dilated ventricle with left and /or right ventricular dysfunction; (2) exclusion of pts with specific cardiomyopathies (Ischemic, valvular, metabolic and general systemic etc). 13 pts underwent coronary angiography. None had significant coronary stenosis. Group B consisted of 55 pts with CAD-CM ( 52 male and 3 female, aged 36-70 years, mean 55.4 ±9.3 years). Diagnostic criteria were (1) dilated left ventricle; (2) at least one significant coronary stenosis (defined as diameter narrowing > 50%); (3)left ventricular dysfunction without a discrete aneurysm.^99mTc-MIBI myocardial perfusion imaging was performed with the Siemens multiple SPECT 3. The ¹⁸F-FDG myocardial metabolic imaging was performed with PET- B03 system made in China.Images were analyzed using visual and quantitative methods. The left ventricle...