Mechanism And Treatment Of Traffic Lung Injury Of Animal Passengers

Road traffic accident has been threatening human life and is now the first public health issue in the world. In traffic injuries, impact chest injury has high mortality rate, with the lung as the main involved organ, of which the injury severity directly affects prognosis and treatment of traffic injuries and is critical for better life quality post injury.Acute lung injury (ALI) is a secondary injury which is commonly seen after close chest trauma. Furthermore, it may in turn result in acute respiratory distress syndrome (ARDS). It is an important research task at present to prevent ALI from deteriorating to ARDS, which is key to successful prevention and treatment of ARDS. In ALI, endothelial cells of microvessel as main components of blood gas barrier, are the action target cells during cascade reaction of injury inflammation and actively take part in such action, exerting important effect on permeability and blood gas exchange of the pulmonary vascular endothelium. The previous study showed that rearrangement and content change of fibrous actin (F-actin) plays a vital role in permeability enhancement of the endothelium. We assume that satisfactory treatment result for ALI may be attained by inhibiting cell rearrangement of microvascular endothelium, ameliorating vascular endothelial barrier, limiting leakage of liquid and proteins and preventing aggravation of pulmonary edema.In our study, ALI induced by collision of real car containing animals was used to systemically observe the characteristics of microvascular endothelium in ALI at levels of whole body, organ, cell and molecule, and determine the treatment effect of fructose 1,6-disphosphate (FDP) and Shenfu on ALI and their action mechanism.Main study methods and conclusions are as follows:1. By using experimental platform of orbital biological collision, collision experiment was performed in real car carrying animals with different collision modes and speeds to observe and analyze the induced injuries of the car-carried animals at levels of whole body and organ. The results showed that collision speed and collided site of animal were two key factors for severity of injury. Higher collision speed inflicted more severe injury and higher mortality rate. Compared with lateral or angular collision, direct obverse collision induced...