Coronary Vasculoprotective Effect Of Insulin In Myocardial Ischemia-reperfusion And Its Mechanism Of Action

BackgroundGrowing evidence from both animal experiments and clinical observations indicates that endothelial dysfunction contributes significantly to subsequent functional and cellular injury through a variety of pathological pathways in myocardial ischemia/reperfusion (MI/R). Considerable evidence exists that coronary artery endothelial apoptosis plays a critical role in myocardial reperfusion injury. Therefore, treatment that reduces coronary endothelial apoptosis may be a novel approach that can reduce ultimate cardiomyocyte death after ischemia and reperfusion. Although our previous work have demonstrated that PI3K-Akt-eNOS pathway is required for insulin's cardiomyocyte protective effects. Whether insulin may exert a coronary artery endothelial protective effect via Akt-mediated eNOS activation pathway remains unknown.Nitric Oxide (NO) plays an important role in the protection against the onset and progression of cardiovascular disease. Numerous experimental results have demonstrated that low concentrations of NO produced from...