Pharmacodynamic Study On Nanoemulsion-encapsulated Tumor Specific Antigen Protein Vaccine

Tumor is a big threat against people's health and life. The available protocols such as surgery, radiotherapy and chemotherapy are far from satisfaction. With the progress in immunology, cellular biology and molecular biology, tumor vaccines are regarded as the most attractive method and play an important role in prevention and therapy of tumor. However, the potency of tumor vaccines is not so forceful. The lack of tumor specific antigens, the short of effective antigen-present, the limitation of MHC, the polymorph of tumor cells and the low bioavailability are the major factors. The melanoma antigen (MAGE) was the first reported example of tumor specific antigens. MAGE-1 is one important number of MAGE. MAGE-1, expressing in most malignant tumors but not in normal tissue except for testis and placenta, has been used as the ideal target. The MAGE-1 vaccines can induce specific CTL and show potency in tumor immunotherapy. As molecular chaperone, heat shock protein (HSP) participates in processing and presentation of tumor antigen and plays an important role in eliciting antitumor immunity. Recent researches have demonstrated that linkage...